In vitro metabolism studies can exclude the interference of the body factors for the overall experiment to provide a reliable theoretical basis for the low metabolic rate in vivo, toxic and lack of sensitive detection means of drugs, in vitro metabolism research is a good means of research. At present, in vitro models of drug metabolism include microsomal models, gene recombination enzyme models, hepatocyte models, hepatobiliary perfusion models, Liver tissue sections and so on.
Metabolic stability is a key drug property, which is important for both drug administration regiment design as well as toxicity. Species comparison in metabolic stability allows the determination of which animal species is the most appropriate model for the estimation of human metabolic stability of the test article. The use of liver microsomes allows the evaluation of metabolic stability as results of phase I oxidation. The use of hepatocytes allows the evaluation of both phase I oxidation and phase II conjugation.
Medicilon pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and Bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and hamster. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai Government.
Available Studies Include
– Method Development and Validation (GLP & Non-GLP)
– Pharmacokinetics (Tumor bearing rodents, bioavailability, crossover studies, cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB penetration)
– Stability in Vehicles and Plasma
– Drug Interaction Studies
– In vitro Metabolic Stability
– Prediction and Identification of Major Metabolites
– Toxic Kinetics Analysis
– Distribution Studies