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Drug Safety Evaluation Center The drug safety evaluation package research data provided by Medicilon puya was reported to CFDA, the US FDA, and the Australian TGA 15 times for Investigational New Drug (IND for short). , Australia TGA declared Investigational New Drug (IND) more than 60 times. “Medicilon Drug Safety Evaluation Service Project” Drug SafetyRead more

Shanghai Medicilon has extensive experience in pharmacokinetics. Our pharmacy section provides customers with high-quality pharmacokinetic services from all small molecules to large molecules (proteins and antibodies), including in vitro ADME and in vivo pharmacokinetics and biological analysis. The animal species involved are non-human primates, dogs, mice, rats, rabbits, guinea pigs, etc. Among them, non-primate platformsRead more

Metabonomics (metabonomics) refers to the analysis of group indicators, high-throughput detection and data processing, and the dynamic metabolic changes of the overall body or tissue cell system of graduate students, especially for endogenous metabolism, genetic variation, environmental changes and even various. The subject of the characteristics and effects of substances entering the metabolic system. MetabolomicsRead more

Late nineteenth century A 42-year-old woman with leukemia suddenly recovered after a suspected infection with influenza virus. 1912 Italian doctors reported a case in which a patient with advanced cervical cancer had a significant remission after injection of rabies vaccine. The above seemingly bizarre cases have opened up new ideas for tumor immunity, that is,Read more

As researchers continue to explore new drug research and development, in recent years, there have emerged like protein motion (Protein Motion), targeted protein degradation complexes (PROTACs), gene transcription simulation (Transcriptional mimetic), small molecule co-receptor targeting ( SMART) and other emerging drug research and development technologies. As far as the overall development of drug research andRead more

ICH recommended standard genotoxicity test combination Combination one a.Ames b. In vitro chromosome aberration test or in vitro micronucleus test or in vitro mouse lymphoma tk test, one of these three tests can be selected. c. In vivo micronucleus test or in vivo bone marrow cell chromosome aberration test; taking peripheral blood lymphocytes for cytogeneticRead more

1. Preclinical drug research (1) Pre-clinical research content 1. Literature research includes drug name and naming basis, the purpose and basis of the topic. 2. Pharmacy research. Raw material technology research, formulation prescription and technology research, confirmation of chemical structure or component test, drug quality test, drug standard drafting and description, sample inspection, auxiliary materials,Read more

Bioequivalence If the drug concentration is related to the therapeutic effect, it is assumed that the same subject takes different preparations and then measures the drug concentration in the blood at different time points. If the same blood drug concentration-time curve is obtained, it means that the same effect can be produced at the siteRead more

Medicilon Medicinal Chemistry Service Project Medicilon has completed dozens of drug R&D cooperation projects with domestic and foreign customers, and has successfully discovered multiple preclinical drug candidates. Medicilon’s medicinal chemistry team can provide customers with the following services: view details Feasibility assessment of new drug targets High-throughput screening and discovery of active compounds based onRead more

Tumor cell migration is one of the most important features of malignant tumors. Tumor cells invade blood vessels or lymphatic vessels or body cavities from their primary site, and some cells are brought to another site or organ by blood and lymph fluid, where they multiply and grow to form The same type of tumorRead more