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On April 8, 2021, the clinical trial application of HG381 for injection, developed by HitGen, was approved by National Medical Products Administration (NMPA).  HG381 for injection is a new Category I Chemical Drug and is clinically intended to be used for the treatment of advanced tumors. HG381 is new molecular entity developed by HitGen basedRead more

Background        In recent years, many drugs have been withdrawn from the market due to sudden cardiac deaths. In the pre-clinical research phase of drugs, 24% of the drugs were discontinued due to cardiovascular side effects, and 45% of the drugs were withdrawn from the market due to cardiac side effects. The main reasons forRead more

Spero Therapeutics (SPRO) has announced that the U.S. Food and Drug Administration (FDA) has notified the suspension of its SPR720 Phase IIA clinical trial. SPR720 is a new type of antibacterial agent that targets enzymes necessary for bacterial DNA replication. SPR720 comes from Vertex and is currently being developed by Spero as an oral therapyRead more

Buffer replacement during protein purification To ensure that the proteins are in the same buffer system as those used in the downstream purification process.That is, the pH value and salt concentration of the environment where the protein is located should be consistent with the purification process, in order to optimize the purification process. Increase theRead more

The purpose of protein purification is to separate the target protein from all the components of the cell lysate, while still retaining the biological activity and chemical integrity of the protein. The separation and purification of protein is an arduous and arduous task. It is necessary to select an appropriate purification method according to theRead more