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The largest study of CRISPR action to date has developed a method to predict the exact mutations CRISPR-Cas9 gene editing can introduce to a cell. Researchers at the Wellcome Sanger Institute edited 40,000 different pieces of DNA and analysed a thousand million resulting DNA sequences to reveal the effects of the gene editing and developRead more

Researchers at the University of California, San Francisco (UCSF) report that they have discovered why some lung cancers become drug-resistant after initially responding to targeted therapies. In the process, they say they devised a new two-pronged approach that yields an effective treatment for these cancers in the laboratory and holds promise for the future ofRead more

An international team of scientists has identified a protein that boosts the energy-burning activity of brown fat in mice, and which could feasibly lead to the development of new therapeutic approaches for treating obesity in humans. The research, headed by a team at the University of Cambridge, U.K., showed that the protein, BMP8b, effectively superchargesRead more

Imagine a DNA database populated with data from every individual in society and made available to law enforcement. Such a database sounds ominous, especially if you’ve watched Black Mirror or similarly dystopian-themed programs. But such a DNA database could also be reassuring, suggests a team of scientific and policy experts at Vanderbilt University. According toRead more

Understanding the genetic makeup of complex chronic diseases is a significant step toward developing advanced diagnostics and better treatment options. In that vein, an international team of investigators led by scientists at the University of Manchester put together an extensive genome-wide association study (GWAS) to identify the genetic factors that predispose people to chronic kidneyRead more