Our Discovery Biology department offers services supporting structure-based drug discovery from determination of novel targets to final structures. Our platform is one of the earliest established structural biology platforms in China and has been certified by the Shanghai Government.
Technology Platforms
Kinase Assay: VEGFR2 I
Protease Assay: Renin inhibition using FRET
Validated Enzymatic Targets
Abl
AKT1
AKT2
AKT3
ALK
Aurora A
Aurora B
B-Raf
BTK
Cathepsin K/L/B/S
CDK/P25
CHK1
CHK2
c-Kit
c-Met
COX-1/COX-2
C-Raf
DPPIV
EGFR
EGFR (L858R/T790M)
Factor Xa
FGFR1
Flt1/VEGFR1
Flt3
Flt4
α- Glucosidase
β- Glucosidase
GSK3 beta
H+/K+ ATPase
HDAC1 &HDACs
HER2
IKK beta
JAK1
JAK2
JAK3
LCK
Lipoxygenase
Lyn
MAPK14
MARK1
MEK1
MEK2
mTOR
PDE5
PDGFR beta
PI3K alpha
PI3K beta
PI3K delta
PI3K gamma
PKA
PKC delta
PKC gamma
Plk1
20S proteasome
Renin
SAHase
SGK1
SRC
Syk
VEGFR2
Note: The enzyme in blue is Kinase
Cytotoxicity Assay Using celltiter glo
Cell-based Cathepsin Assay for irreversible inhibitors
Cell Cycle Analysis Using Flow Cytometry
Expression level of Phospho-Akt and Akt in mouse tumor
Cytotoxicity Assay Using celltiter glo
Cell-based Cathepsin Assay for irreversible inhibitors
Pre-migration
Post-migration
Background
Positive control
Technology Platforms （3H， 33P, 32P, 35S, 125I，14C）
Receptor binding assay-3H
3H-5HT uptake assay-3H
Radioactive iodine uptake assay-125I
