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In Vitro Assays

Home Service In Vitro Assays

Our pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME assays.

Pharmacokinetic In Vitro Assays

Our pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and hamster. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai Government.

Available Studies Include:

  • Method Development and Validation (GLP & Non-GLP)
  • Bioanalysis
  • Pharmacokinetics (Tumor bearing rodents, Bioavailability, Crossover studies, Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB penetration )
  • Stability in Vehicles and Plasma
  • Drug Interaction Studies
  • In vitro Metabolic Stability
  • Prediction and Identification of Major Metabolites
  • Toxicokinetics Analysis
  • Distribution Studies

Pharmacokinetics Package for IND Filing

DMPK package for CFDA and FDA IND filing

  • Chemical Compounds
  • Traditional Chinese Medicine
  • Protein
  • Antibody

Metabolic Stability Services

  • CYP Reaction Phenotyping
  • Microsomal Stability
  • S9 Stability
  • Hepatocyte Stability
  • Plasma Stability
  • Metabolite Profiling & Identification

Drug-Drug Interaction Services

  • Cytochrome P450 and UGT Reaction Phenotyping
  • Hepatocyte Induction
  • Cytochrome P450 Inhibition
  • Time Dependent Inhibition (Single Point)

Permeability and Transporter Services

  • Caco-2 Permeability
  • P-gp Inhibition

Available Reaction Phenotyping Services Include:

  • Phase I:
  • Cytochrome P450 Enzymes (CYP)
  • Phase II:
  • UDP-glucuronyltransferases (UGT)

Metabolic Stability

  • Microsomes Stability
  • Hepatocytes Stability
  • Plasma Stability
  • S9 Stability

Protein Binding Services

  • Plasma Protein Binding
  • Brain Tissue Binding
  • Whole Blood Binding
  • Blood to Plasma Ratio

Related Services Preclinical Services, MetID Services

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  • Formulation Development
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Shanghai Medicilon Inc.

Address: No. 585, Chuanda Road, Pudong, Shanghai, 201200, China
Email: Marketing@medicilon.com
Website: www.medicilon.com

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  • Home
  • About
    • Medicilon Overview
    • Executive Team
    • CEO Message
    • Corporate Culture
    • Company History
    • Honor
  • Services
    • Integrated Projects
      • Antibody-Drug-Antibody (ADC)
      • Preclinical Research Services
      • IND Filing
      • Bio Drug Development
      • Chemical Drug Development
      • Chemical Compound Druggability Assessment
      • Molecular Imaging & Radiochemistry
      • OINDP Development
      • Preclinical Ophthalmic Research Platform
    • Pharmacology Services
      • Cancer Xenograft Models
      • Orthotopic Models
      • Syngeneic Mouse Models
      • Transgenic Mouse Model
      • Humanized Mouse Model (hPBMCEngrafted)
      • PDX Model
      • Digestive System Models
      • Neurological Disorders Models
      • Metabolic Disease Models
      • Inflammation & Immunological Disease Models
      • Other Disease Models
    • Chemistry Services
      • Medicinal Chemistry Services
      • Synthetic Chemistry
      • Process Development Services
      • Analytical Chemistry
    • Drug Formulation
      • Pre Formulation Development
      • Analytical Development
      • Formulation Development Services
      • Generics Consistency Evaluation
      • Research on Quality Control
      • Clinical Trial Material
      • OINDP Development
    • Biology Services
      • Discovery Biology Services
      • Recombinant Protein Services
      • Computational Biology & Molecular Modeling
      • Crystallization & Structural Determination
      • Kinase Services
      • SeMet Media Sales
    • Bioanalytical Services
      • Large Molecule Bioanalysis
      • Small Molecule Bioanalysis
    • Pharmacokinetic Services
      • In Vivo Assays
      • In Vitro Assays
    • Drug Safety Evaluation
      • Inhalation Toxicity Assessment
  • Customer
    • Customer Reviews
    • New Models of Collaboration
    • Intellectual Property Protection
    • Download Center
  • Careers
  • News
    • Medicilon Events
    • Media Coverage
    • Featured Stories
  • Contact
Medicilon Inc