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Molecular Imaging & Radiochemistry

Home Service Molecular Imaging & Radiochemistry

PET is an imaging technique that complements MRI and CT imaging. MRI and CT provide non-physiological, high-resolution anatomical images that can often reveal important information on the status of disease. Obtaining physiological information on diseased tissue can aid in diagnosis and help direct the proper course of treatment. PET is inherently based on physiological imaging. For PET a radionuclide is bound to a molecule of pharmacologic significance. The compound is administered and the images obtained with a PET scanner reveal localization of the pharmaceutical in the body.

Molecular Imaging & Radiochemistry

Committed to PET imaging for drug development, drug radio-labeling and molecular tracer research, tumor targeted therapy technology, we will have implementation of platform construction for PET molecular imaging drug screening and preclinical evaluation. This platform will serve for global on medical imaging in the field of drug research. With the technology, knowledge and experience of the world’s leading professionals, we will use resources of small animal and non-human primates to create a novel method to establish PET imaging for drug screening in preclinical trials and clinical Phase 0 studies.

Phase 0 studies, also called micro-dosing studies, are a new regulatory category, guided by the EMEA (CPMP/SWP/2599/02, 2003) and FDA (Exploratory IND draft, 2005) allowing to perform human studies with a considerably reduced tox package, compared to a conventional first in human study, provided that not more than 100 µg substance are administered.

For CNS drug candidates, microdosing is of special interest to investigate BBB penetration, receptor binding, or dose-to-target-organ relationships. Also, first evidence on metabolism can be obtained. Microdosing represents a considerable cost and time advantage and helps to minimize attrition rates in CNS compound development.

Radioactive-TLC

△Radioactive-TLC

Radioactive-HPLC

△Radioactive-HPLC

PET-CT Mice

PET & Pharmacology Studies

–With radioactive tracers, we can assess metabolic or synthetic rates of specific substance, thus allowing the evaluation of the functional status and integrity of the tissue.

–With radioactive ligands, we can be measure the concentration of specific receptor or transporter sites, thus allowing the evaluation of the integrity or distribution of specific targets that may correspond to their expression.

–With quantitative chamber analysis, we can be detect the potential confusion of blood flow differences.

PET is used to predict the long-term efficacy of a drug

△PET is used to predict the long-term efficacy of a drug

PET & PK Studies

Radioactive tracer labeled PET studies can quantitatively evaluate the pharmacokinetics and metabolism of drugs. Combined with pharmacodynamic data such as behavior, pharmacokinetic PET study can help researchers establish dose-response relationship and determine dosage. Additionally, PET can also track the distribution of drugs in target tissues.

PET is used to predict the long-term efficacy of a drug△The target effect diagram of 64Cu labeled PD-1

Imaging Mice Medicilon△Left:Dynamic distribution of drugs in the abdominal cavity of mice

Imaging Mice△Right:The drug is distributed across regions of the brain

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  • Home
  • About
    • Medicilon Overview
    • Executive Team
    • CEO Message
    • Corporate Culture
    • Company History
    • Honor
  • Services
    • Integrated Projects
      • Antibody-Drug-Antibody (ADC)
      • Preclinical Research Services
      • IND Filing
      • Bio Drug Development
      • Chemical Drug Development
      • Chemical Compound Druggability Assessment
      • Molecular Imaging & Radiochemistry
      • OINDP Development
      • Preclinical Ophthalmic Research Platform
    • Pharmacology Services
      • Cancer Xenograft Models
      • Orthotopic Models
      • Syngeneic Mouse Models
      • Transgenic Mouse Model
      • Humanized Mouse Model (hPBMCEngrafted)
      • PDX Model
      • Digestive System Models
      • Neurological Disorders Models
      • Metabolic Disease Models
      • Inflammation & Immunological Disease Models
      • Other Disease Models
    • Chemistry Services
      • Medicinal Chemistry Services
      • Synthetic Chemistry
      • Process Development Services
      • Analytical Chemistry
    • Drug Formulation
      • Pre Formulation Development
      • Analytical Development
      • Formulation Development Services
      • Generics Consistency Evaluation
      • Research on Quality Control
      • Clinical Trial Material
      • OINDP Development
    • Biology Services
      • Discovery Biology Services
      • Recombinant Protein Services
      • Computational Biology & Molecular Modeling
      • Crystallization & Structural Determination
      • Kinase Services
      • SeMet Media Sales
    • Bioanalytical Services
      • Large Molecule Bioanalysis
      • Small Molecule Bioanalysis
    • Pharmacokinetic Services
      • In Vivo Assays
      • In Vitro Assays
    • Drug Safety Evaluation
      • Inhalation Toxicity Assessment
  • Customer
    • Customer Reviews
    • New Models of Collaboration
    • Intellectual Property Protection
    • Download Center
  • Careers
  • News
    • Medicilon Events
    • Media Coverage
    • Featured Stories
  • Contact
Medicilon Inc