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Shanghai Medicilon has extensive experience in pharmacokinetics. Our pharmacy section provides customers with high-quality pharmacokinetic services from all small molecules to large molecules (proteins and antibodies), including in vitro ADME and in vivo pharmacokinetics and biological analysis. The animal species involved are non-human primates, dogs, mice, rats, rabbits, guinea pigs, etc. Among them, non-primate platformsRead more

Pharmacokinetic research is to reveal the dynamic changes of the drug in the body through the research methods of animal in vivo, external and human in vitro, obtain the basic kinetic parameters of the drug, clarify the process and characteristics of drug absorption, distribution, metabolism and excretion. Pharmaceutics, pharmacodynamics, safety evaluation research and clinical researchRead more

ADME studies-ADME is an abbreviation in pharmacokinetics and pharmacology, stands for absorption, distribution, metabolism and elimination of chemicals and drugs to define the impact in a human body. Toxicology testing is a significant event before an introduction of new drugs into the market. However, drug development is a very crucial stage of the pharmaceutical andRead more

Toxicokinetics is essentially the study of “how a substance gets into the body and what happens to it in the body”. Four processes are involved in toxicokinetics. The study of the kinetics (movement) of chemicals was originally conducted with pharmaceuticals and thus the term pharmacokinetics became commonly used. In addition, toxicology studies were initially conductedRead more

Pre-Clinical Safety Pharmacology Studies (Pharmacology) Pharmacology studies can be divided into three categories: primary pharmacodynamic, secondary pharmacodynamic and safety pharmacology studies. Primary Pharmacology Studies Investigate the mode of action and/or effects of a substance in relation to its desired therapeutic target Secondary Pharmacology Studies Investigate the mode of action and/or effects of a substance notRead more

Non-clinical pharmacokinetic studies are based on animal, external and human research methods to reveal the dynamic changes in drugs in vivo, to obtain the basic pharmacokinetic parameters of drugs to elucidate the absorption, distribution, metabolism and excretion of drugs process and characteristics. The main contents of nonclinical pharmacokinetic studies include plasma concentration-time curve determination, absorption,Read more

Pharmacokinetic / pharmacodynamics (PK/PD) modeling, an integral component of the drug development process, is a mathematical technique for predicting the effect and efficacy of drug dosing over time. Broadly speaking, pharmacokinetic models describe how the body reacts to a drug in terms of absorption, distribution, metabolism, and excretion. Pharmacodynamic models describe how a drug affectsRead more

DMPK or Drug Metabolism and Pharmacokinetics is a major part of studies related to drugs often referred to as ADME (Absorption, Distribution, Metabolism and Elimination). It is concerned with the study of aspects of absorption, distribution, metabolism and elimination of drug compounds which are administered through any route of administration. Drug Metabolish and Pharmacokinetics areRead more