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Racial /Ethnical sensitivity is an important factor that affects the effectiveness and safety of drugs in different ethnic groups. Among them, pharmacokinetics (PK) is the most important source of drug racial sensitivity. one. According to the definition of racial factors in ICHE5 [1], factors that cause racial differences include internal factors such as genetics andRead more

Pharmacology is the science of studying the dosage, mechanism of action and curative effect of drugs. The core of pharmacology is the study of pharmacokinetics and pharmacodynamics. What is pharmacokinetics, pharmacodynamics and pharmacokinetics/pharmacodynamics? Pharmacokinetics studies the concentration of drugs in the body at different time points. On the other hand, pharmacodynamics studies the relationship betweenRead more

Shanghai Medicilon has extensive experience in pharmacokinetics. Our pharmacy section provides customers with high-quality pharmacokinetic services from all small molecules to large molecules (proteins and antibodies), including in vitro ADME and in vivo pharmacokinetics and biological analysis. The animal species involved are non-human primates, dogs, mice, rats, rabbits, guinea pigs, etc. Among them, non-primate platformsRead more

Pharmacokinetic research is to reveal the dynamic changes of the drug in the body through the research methods of animal in vivo, external and human in vitro, obtain the basic kinetic parameters of the drug, clarify the process and characteristics of drug absorption, distribution, metabolism and excretion. Pharmaceutics, pharmacodynamics, safety evaluation research and clinical researchRead more

ADME studies–ADME is an abbreviation in pharmacokinetics and pharmacology, stands for absorption, distribution, metabolism and elimination of chemicals and drugs to define the impact in a human body. Toxicology testing is a significant event before an introduction of new drugs into the market. However, drug development is a very crucial stage of the pharmaceutical andRead more

Toxicokinetics is essentially the study of “how a substance gets into the body and what happens to it in the body”. Four processes are involved in toxicokinetics. Four processes in toxicokinetics The study of the kinetics (movement) of chemicals was originally conducted with pharmaceuticals and thus the term pharmacokinetics became commonly used. In addition, toxicologyRead more

Non-clinical pharmacokinetic studies are based on animal, external and human research methods to reveal the dynamic changes in drugs in vivo, to obtain the basic pharmacokinetic parameters of drugs to elucidate the absorption, distribution, metabolism and excretion of drugs process and characteristics. The main contents of nonclinical pharmacokinetic studies include plasma concentration-time curve determination, absorption,Read more

Pharmacokinetic / pharmacodynamics (PK/PD) modeling, an integral component of the drug development process, is a mathematical technique for predicting the effect and efficacy of drug dosing over time. Broadly speaking, pharmacokinetic models describe how the body reacts to a drug in terms of absorption, distribution, metabolism, and excretion. Pharmacodynamic models describe how a drug affectsRead more

DMPK or Drug Metabolism and Pharmacokinetics is a major part of studies related to drugs often referred to as ADME (Absorption, Distribution, Metabolism and Elimination). It is concerned with the study of aspects of absorption, distribution, metabolism and elimination of drug compounds which are administered through any route of administration. Drug Metabolish and Pharmacokinetics areRead more