Medicilon Logo
|
search icon search icon language icon contact icon menu icon
Medicilon Logo
|
search icon close search icon language icon contact icon menu icon
logo icon CN
Contact Us
Close Button
Message
Back To Top
Online Message×
Click switch
Close Button
News information

A New Old Protein in B Cells discovered by Scientists

2015-10-15
|
Page View:

    Researchers of the University of Freiburg have discovered a new protein, Kidins220/ARMS, in B cells. They also determined that it plays a critical role in the production of antibodies and the formation of B cells, which are a type of white blood cells.


    Various teams of researchers had already noted that Kidins220/ARMS is present in nerve cells and in T cells of the immune system. However, its presence in B cells was unknown until now.


    “We’ve discovered a new molecular player in the immune system,” said immunobiologist Wolfgang Schamel, adding, “This knowledge could help to develop new medications for autoimmune diseases or other illnesses in the future.”


    A postdoc from the Schamel lab, Gina J. Fiala, Ph.D., is the lead author of the group’s study (“Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation) in the Journal of Experimental Medicine. Dr. Fiala studied Kidins220/ARMS in B cells for her doctoral thesis.


    B cells, which are the only cells to produce antibodies, carry B cell receptors. These activate the B cells when an antigen is found by the immune system. The scientific team discovered that Kidins220/ARMS interacts with the B cell receptor and affects signaling pathways from the receptor to the interior of the cell. Without Kidins220/ARMS, the receptor’s ability to send signals is limited. As a result, the B cells manufacture less antibodies and the immune system is weakened.


    Kidins220/ARMS is also vital for the formation of B cells. If a mouse cannot produce this protein, the B lymphocytes develop in a way that makes them less functional than the B cells of a healthy immune system. The reason for this is that B cells depend on the signals from the B cell receptor and pre-B cell receptor, which is the early version of a B cell receptor, at various stages of their development. Deficiency in Kidins220/ARMS therefore obstructs the development of B cells.

Relevant newsRelevant news