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Analysis of the influence of compound dosage on pharmacological effects

2021-05-06
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In new drug research, determining the dosage of different animals is a problem that needs to be paid attention to in pharmacological research. The pharmacological effect is proportional to the dose of the drug within a certain range, that is, the dose-effect relationship. The dose of the drug has an impact on the effect of the drug, and within a certain range, the dose of the drug is proportional to the intensity of the action. The intensity of the drug’s action will increase with the increase of the dose, but if it exceeds a certain range, poisoning or even death may occur. Moreover, the dosage of some compounds is changed, and the effect is also very different.

The amount of medication refers to the dose, the amount of the drug dose determines the level of the blood concentration, and the blood concentration determines the effect of the drug. The dose-effect relationship is an important reference data for the clinical application of drugs. In short, how many effects can be produced by how many doses. It is impossible to clarify that the dose-effect relationship of the compound will affect the clinical application of the compound. In pharmacological research, the influence of dosage on drug effect is the traditional experimental item of pharmacological confirmatory test.

Drugs refer to substances that can affect the body’s physiological functions and biochemical processes and are used to prevent, diagnose and treat diseases. Pharmacology is a discipline that studies the interaction between drugs and the body (including pathogens) and their laws. Medicilon has a professional team and practical experience in safety pharmacology research, and can provide high-quality data and fast turnaround to support various drug safety evaluation studies.

Within a certain dose range, the larger the drug dose, the higher the blood drug concentration, and the drug effect will also increase. For example, metformin for the treatment of diabetes, insufficient dosage will cause poor blood sugar control, because its hypoglycemic effect increases with the increase in dosage within a certain range. The greater the dosage, the stronger the hypoglycemic effect. However, beyond a certain dose range, as the administered dose increases, the blood concentration will continue to increase, which will cause toxic reactions. Metformin is not that the greater the dose, the better the hypoglycemic effect. It will have certain gastrointestinal reactions, such as nausea, vomiting, abdominal distension, diarrhea and a series of gastrointestinal symptoms; and these symptoms will increase with the increase of the dose. , Even many sugar friends can’t tolerate it.

There will be a maximum dose of any drug. Even if the hypoglycemic effect of metformin increases as the dose increases, it should not be eaten casually. It must be controlled within the maximum dose. In pharmacological research, it is very important to determine the best effective dose of drugs. Regarding drug doses, the pharmacopoeias of various countries have established common dose ranges.

With different dosages, the effects of some drugs have also changed. Different doses of aspirin have different effects. Aspirin enteric-coated tablets have an inhibitory effect on platelet aggregation, and aspirin effervescent tablets have antipyretic and analgesic effects. For example, supplementing a small dose of folic acid during pregnancy can prevent fetal neural tube defects. Another type of folic acid, 5 mg per tablet, is a prescription drug used to treat megaloblastic anemia. The indications of some medicines are not constant, and the pharmacological effects of the medicine may change with the change of the dosage of the medicine.

In short, the dosage of the drug is one of the factors that affect the effect of the drug. Generally speaking, the effect of the drug will increase with the increase of the drug dose, but the increase of this effect is not unlimited. When it increases to a certain degree, The effect of the drug will be constant at a certain level. High doses of drugs can cause poisoning or death. Exploring the optimal dosage of drugs is of great significance for pharmacological research and clinical medication.

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