Stress, anxiety and depression are closely related to the phenomenon, most of the anxiety and depression patients have experienced severe psychological stress events. Thus, stress events are seen as a cause of anxiety and depression, or at least on genetic basis, which can lead to the generation of emotional disorders. Anxiety and Depression Animal models place animals in a series of stress situations (latent or actual threats, acute or chronic) that cause emotional disorders and then apply specific measures to behavioral and physiological indicators Detection, and thus explore the mechanisms of this emotional disorder, as well as the identification and screening of anxiolytics or antidepressants.
Anxiety Animal Model: Anxiety is a pre-known but inevitable, upcoming stress events caused by an expected response to fear, fear, tension and other psychiatric symptoms as the main performance, accompanied by palpitations, sweating, cold hands and feet and other plant neurological disorders, the core symptoms of concern.
In order to prove whether the anxiety model stimulates the animal’s anxiety response should be looking for ways to measure the anxiety response and indicators; the animal’s anxiety response is usually measured using animal behavior or physiological responses to stress or new heterosexual events. These disgusting situations of the animal include open spaces, bright or have a certain height, all of which form the basis for the use of inquiry tests to measure animal anxiety reactions.
The main behavioral indicators include: (1) the inhibition of exploratory behavior, the number of animals to explore the open arm decreased, the time to stay in the open arm to reduce the number of lattice reduction, animals to avoid the bright place; (2) social behavior reduction, mutual sniffing, (3) mutual chase the behavior was significantly reduced, the animals tend to escape other animals.
Depression Animal model: depression shows a depression, slow thinking, and slow behavior as the main symptoms of mental illness, and may be accompanied by reduced sleep, weight and other physical symptoms, uncontrollable stress is an important reason for its production. Thus, the common characteristic of all depressive animal models is that depressive behavior is caused by uncontrollable negative events. At present, the establishment of depression animal models is divided into three categories: behavioral despair, acquired helplessness and chronic mild unpredictable stress.
Medicilon’s Pharmacology department functions in accordance with the needs of our customers for a variety of effective animal models used to detect drug effectiveness. We offer non-human primates, dogs, mice and rats, rabbits, guinea pigs and others in our services. At present, we have various proven effective animal models. Furthermore, our experienced staffs operate with strong theoretical basis. We offer the services which are flexible for custom development of various types of models to meet the requirements of our clients.
Recently, Medicilon appointment Dr. Dong Wenxin as the company’s senior director of pharmacology team. Dr. Dong has long been engaged in pharmacological research, mainly related to depression, Alzheimer’s disease, pain, anxiety, Parkinson’s disease and other fields.
We believe that the addition of Dr. Dong will greatly contribute to the business development and strategic planning of the Medicilon pharmacological team, to further expand the Medicilon effective animal model service platform, improve Medicilon’s effective animal model library to meet the different types of customers new drug research and development needs.