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SARS-CoV-2 is an enveloped single-stranded RNA virus. The viral RNA produces two polyproteins: pp1a and pp1ab through ribosome frameshift. The polyprotein is processed by the papain-like protease (PL pro), which cuts 3 sites to release the non-structural protein nsp1-3 and a 3C-like protease, also known as the main protease (M pro). Cut at 11 sitesRead more

Pharmacokinetics (PK), also known as pharmacokinetics, is a discipline that studies the process of drugs in the body, including the changes in the absorption, distribution, metabolism and excretion of drugs and their metabolites over time, and applied kinetics A quantitative description of this process by principles and mathematical processing methods. Pharmacokinetics is a discipline thatRead more

In the past ten years, the cycle of drug discovery and development has become longer and longer, and the cost of testing has increased. In Western countries, it takes 10 to 15 years to develop and market a new compound entity, and it costs more than US$800 million. Of the 10,000 new compound entities, 10Read more

Due to the combination of tumor and CAR-T immunotherapy, the amazing results produced are exciting. Medicilon followed closely with international companies in tumor models, especially in the field of immune tumor animal model evaluation systems, and introduced internationally advanced PET-CT imaging systems, radiotherapy radiation systems, IVIS small animal imaging systems, multi-channel flow cytometry analyzers, etc.Read more

Glaucoma is the leading cause of irreversible blindness worldwide. This disease causes vision loss when the optic nerve and retinal cells are lost. The etiology of the disease is complex, with a wide range of risk factors. Age, race, family history, myopia, cardiovascular disease, diabetes, abnormal blood rheology, etc. are all risk factors for glaucoma.Read more

On November 11, the team of Chinese-American Wang Shaomeng published a paper titled “A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo” in the scientific journal Cancer Cell, which immediately stirred up thousands of people. Layers of waves have brought PROTAC technology back to people’s sight. Shanghai Medicilon Biopharmaceutical Co.,Read more

The advent of PROTAC The advent of PROTAC has brought solutions to targets that traditional small-molecule drugs cannot be made into. After 2017, PROTAC technology has developed rapidly, from the laboratory to the industrial world, starting from Harvard University, Yale University, Arvinas, C4, Kymera Therapeutics have been established to specialize in PROTAC technical drug research,Read more

The rapid spread of COVID-19 is a public health emergency that has attracted international attention. The clinical situation of COVID-19 is still not fully understood, but it is obviously related to respiratory symptoms, and in some cases it can induce acute multiple organ failure. Respiratory distress syndrome (ARDS), especially in elderly patients with a historyRead more

Particulate preparation refers to a solid, liquid, semi-solid or gaseous pharmaceutical preparation composed of particles with a certain particle size (micron or nanometer) made by a certain dispersion and embedding technology with a suitable carrier (generally a biodegradable material) It has excellent properties such as improving the stability of the drug, reducing adverse drug reactions,Read more

Lung cancer is one of the most common malignant tumors in the world, and it has become the first cause of death from malignant tumors in the urban population of our country. Non-small cell lung cancer (NSCLC) includes squamous cell carcinoma, adenocarcinoma, and large cell carcinoma. Compared with small cell carcinoma, cancer cells grow andRead more