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Salmonella reverse mutation test. The Ames test is currently the internationally recognized test of choice for detecting the mutagenicity and carcinogenicity of new drugs. This test uses the nature of the histidine auxotrophic mutant (His-) of Salmonella typhimurium to produce revertives. Preliminary screening of the mutagenicity of chemical substances. The study found that the concentrationRead more

The test designed to study the toxicity caused by topical medication is a local toxicity test, which is an important part of toxicology research, including irritation test, allergic test, hemolysis and skin toxicity test. Generally speaking, ointments, drops, lotions, scalp patches, sprays, powders for external use and other dosage forms must be tested for localRead more

For pharmaceutical R&D personnel, the amount of data in pharmaceutical research is very large. Integrating such a large amount of data is a very complicated task. Compared with traditional paper declaration, electronic drug declaration has many obvious advantages. For example, the SEND format can integrate data into a SEND data set, and visual tools canRead more

Targeted aquaporin 4 (AQP4) is abundantly distributed in the central nervous system, and is involved in the reabsorption of cerebrospinal fluid, osmotic pressure regulation, etc., and is related to the occurrence of cerebral edema and spinal cord edema. Recently, it was published in the latest issue of the scientific journal Cell that targeting aquaporin-4 subcellularRead more

In new drug research, determining the dosage of different animals is a problem that needs to be paid attention to in pharmacological research. The pharmacological effect is proportional to the dose of the drug within a certain range, that is, the dose-effect relationship. The dose of the drug has an impact on the effect ofRead more

Insect cell baculovirus vector expression system is widely used in the production of recombinant proteins. Compared with typical E. coli and yeast expression systems, it has a powerful polyhedrin promoter, so it has high expression performance and can perform correctly. The post-translational modification to produce functional and immunogenetic active recombinant protein. Moreover, the virus andRead more

Caveolin exists in a variety of terminally differentiated cells such as fibroblasts, endothelial cells, and type I alveolar epithelium. It is a flask-shaped micro-recessed structure with a diameter of 50-100 nm on the cytoplasmic membrane. Caveolin-1 protein is the cellar Important structural protein. Studies have suggested that Caveolin-1 participates in the regulation of the activityRead more

Baculovirus is a larger type of insect virus. It can not only be used as an important biological insecticide, but also can be used in baculovirus vector expression system. It has excellent performance in agriculture, basic molecular biology and medicine. Its important role. In the field of biological science research, the use of a baculovirusRead more

Yeast is a single-celled lower eukaryote with ordinary culture conditions, rapid growth and reproduction, and can tolerate high hydrostatic pressure. It can be mass-produced when used to express genetic engineering products, effectively reducing production costs. The vector of the yeast expression system is generally a shuttle plasmid, which belongs to the E. coli-yeast shuttle vector,Read more

Both CD4 molecule and IL-12 are hot molecules in tumor immunotherapy research. Among them, CD4 molecule has important immunological functions, it can participate in the body’s immune response, and the cytokines of the IL-12 family of interleukins play a role in immune regulation. The immune response can be formed by directly inducing the development ofRead more