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FAQs

FAQs
What are inhaled liquid formulations and inhaled liquid formulations include?
Inhalation liquid formulation is a dosage form of oral inhalation formulation, which refers to the liquid formulation for nebulizer, that is, through the nebulizer to produce continuous aerosol solution for inhalation, suspension, etc.
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What is the definition of inhalation formulation?
Inhalation formulation refer to formulations in which a drug is delivered to the respiratory tract and/or lungs in the form of a mist through a specific device for local or systemic action.
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What is the Classification of Therapeutic Approaches in Immuno-Oncology?
1.Passive immunity [acting on tumors] • Anti-tumor monoclonal antibody EGFR, Her2 monoclonal antibody • Adoptive immunotherapy adoptive cell transfer, CAR-T
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What is the List of ADC Payload?
1. 5-substituted 2' -deoxyuridine analogues 2. Rixix analogues 3. Pyrophosphate analogs 4. NRTI drugs 5. NNRTIs
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What are Potential Causes of Polypeptide Instability?
• Deamidation reaction: non-enzymatic catalyzed deamidation reaction, which is related to environmental conditions and polypeptide structure
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Typical Characteristics Affecting Bioanalysis
Not too small or large molecular weight Semi-antigenic properties
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Common Platform for Polypeptide Drug Bioanalysis
LC-MS/MS Ligand Binding assays: EIA, FIA, ECL, RIA, CLIA, etc
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Key Aspects of Polypeptide Drug Bioanalysis
​PK, TK ADA
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What are Advantages of Peptides?
Advantages and Features Significant activity, strong specificity, good affinity with receptors, weak toxicity, generally not easy to accumulate in the body.
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Where do Polypeptides Come From?
•Natural extract peptide: such as bone peptides •Chemical synthesis: exenatide, natriuretic peptide, Bremelanotide (2019.6), Afanotide (2019), etc.
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