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FAQs

FAQs
What is PDXO Model?
PDX-derived organoid or PDXO model is an in vitro model that inherits most of the advantages of PDX models.
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What is PDX Model?
Patient-derived xenograft or PDX model is now recognized as the best in vivo model for predicting clinical outcomes.
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What are inhaled liquid formulations and inhaled liquid formulations include?
Inhalation liquid formulation is a dosage form of oral inhalation formulation, which refers to the liquid formulation for nebulizer, that is, through the nebulizer to produce continuous aerosol solution for inhalation, suspension, etc.
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What is the definition of inhalation formulation?
Inhalation formulation refer to formulations in which a drug is delivered to the respiratory tract and/or lungs in the form of a mist through a specific device for local or systemic action.
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What is the Classification of Therapeutic Approaches in Immuno-Oncology?
1.Passive immunity [acting on tumors] • Anti-tumor monoclonal antibody EGFR, Her2 monoclonal antibody • Adoptive immunotherapy adoptive cell transfer, CAR-T
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What is the List of ADC Payload?
1. 5-substituted 2' -deoxyuridine analogues 2. Rixix analogues 3. Pyrophosphate analogs 4. NRTI drugs 5. NNRTIs
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What are Potential Causes of Polypeptide Instability?
• Deamidation reaction: non-enzymatic catalyzed deamidation reaction, which is related to environmental conditions and polypeptide structure
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Typical Characteristics Affecting Bioanalysis
Not too small or large molecular weight Semi-antigenic properties
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Common Platform for Polypeptide Drug Bioanalysis
LC-MS/MS Ligand Binding assays: EIA, FIA, ECL, RIA, CLIA, etc
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Key Aspects of Polypeptide Drug Bioanalysis
​PK, TK ADA
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