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FAQs

FAQs
What is the Classification of Therapeutic Approaches in Immuno-Oncology?
1.Passive immunity [acting on tumors] • Anti-tumor monoclonal antibody EGFR, Her2 monoclonal antibody • Adoptive immunotherapy adoptive cell transfer, CAR-T
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What is the List of ADC Payload?
5-substituted 2' -deoxyuridine analogues (e.g., Aufudine) Rixix analogues (e.g. Entecavir) Pyrophosphate analogs (e.g., Sodium terephthalate) NRTI drugs (e.g. Lamivudine) NNRTIs (e.g., Nevex leveling)
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What are Potential Causes of Polypeptide Instability?
• Deamidation reaction: non-enzymatic catalyzed deamidation reaction, which is related to environmental conditions and polypeptide structure
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Typical Characteristics Affecting Bioanalysis
Not too small or large molecular weight Semi-antigenic properties
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Common Platform for Polypeptide Drug Bioanalysis
LC-MS/MS Ligand Binding assays: EIA, FIA, ECL, RIA, CLIA, etc
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Key Aspects of Polypeptide Drug Bioanalysis
​PK, TK ADA
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What are Advantages of Peptides?
Advantages and Features Significant activity, strong specificity, good affinity with receptors, weak toxicity, generally not easy to accumulate in the body.
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Where do Polypeptides Come From?
•Natural extract peptide: such as bone peptides •Chemical synthesis: exenatide, natriuretic peptide, Bremelanotide (2019.6), Afanotide (2019), etc.
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What are Polypeptides?
Chemical synthesis, larger than 40 amino acids but less than 100 amino acids (FDA, FDA-2018-N-2732, 2018) Peptides generally refer to a class of compounds formed by dehydration and condensation of 3-50 A-amino acids.
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What is New Drug Development for Diabetes?
Ultra-short-acting insulin,Short-acting insulin ,Intermediate-acting insulin,Long-acting insulin
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