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FAQs

What are the Advantages and Disdvantages of RNA?

RNA: by degrading target mRNA

Advantage:

    Can be delivered to cross the cell membrane

    Can achieve high potencies for their targets

    siRNA molecules tend to exhibit longer persistence of target mRNA knockdown.

Disadvantage:

    High metabolic instability

    Off-target effects

    Poor cell permeability

    Low bioavailability, Hepatotoxicity, poor PK and limited tissue distribution, poor solubility and stability, only target liver diseases