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Classification Based on the Structural Form of Bispecific Antibodies

1) IgG-like bispecific antibody: 

Igg-like BsAb has an Fc part and has Fc-mediated effect function, such as antibody-dependent cell-mediated cytotoxicity (ADCC), complement-dependent cytotoxicity (CDC), and antibody-dependent cell-mediated phagocytosis (ADCP). The Fc part of the antibody is helpful to the purification and improves its solubility and stability in the later stage. The relative molecular weight of IGG-like BsAb is more significant, and the Fc part binds to the receptor FcRn, increasing the antibody's serum half-life. Antibody-like structures include Triomabs/quadroma, DVD-LG (dual variable domain Ig), CrossMAb, Two-in-one IgG, and scFv2-Fc. 

2) Non-IGg-like bispecific antibody: 

Non-LGG-like BsAb lacks Fc fragments and plays a therapeutic role only through antigen binding. It is characterized by low immunogenicity, easy production, and small molecular weight. Because of its relatively small molecular weight, its permeability in tumor tissue is higher, so it has a more substantial therapeutic effect. These BSABs come in many forms, including TandAb (tandem diabody), scFv-HSA-scFv, BiTE (bi-specific T-cell engager), and DART (dual) Affinityretargeting), Nanobody.