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FAQs

What are Features of Ideal DMPK?

Complete absorption (passive absorption is better), bioavailability > 50% and small variation;

AUC is proportional to dose, and PK/PD correlation is clear; 

Quickly reach the target organ and do not accumulate outside the target organ;  PPB<90%, not affected by concentration and time; 

Plasma clearance CL<30%Qn, cleared through various routes;

Age, race, gender, disease state, etc. have little effect on CL;metabolite quantity is low and no reactive metabolites are produced;

Does not inhibit or induce major drug metabolizing enzymes and transporters, and is not affected by food; T1/2>6hr in human body, which can reduce the dosing frequency and improve the compliance.