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FAQs

When to Choose a Metastable Crystal Structure for Development?

The solubility and bioavailability of stable crystals are too low

A fast-release agent with a high dissolution rate is required 

Polycrystalline forms will also have different mechanical properties, such as hardness, powder fluidity, compressibility, and bonding strength.

Manufacturing difficulty 

IP issues 

Chemical instability of thermodynamically stabilized crystals due to topological chemical factors