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FAQs

Preclinical Research Animal Models of Commonly Used CAR-T Cell Products

a) Syngeneic Mouse model with complete immune system
    Burdened murine tumor
    Mouse-derived CAR-T cells for detection of on-target and off-target toxicity

b) Transgenic Mouse with normal immune system
    Express human TAA
    Mouse-derived cell
    Proof-of-concept study

c) Xenograft mouse model (Human Xenograft Mouse)
    Immunodeficient mice
    Human-derived tumor
    Direct proof-of-concept studies

d) Humanized Immune System mice (Humanized Immune System mice, HIS mice)