What are PK Characteristics of Monoclonal Antibodies and Small Molecule Drugs?

Q: What are PK Characteristics of Monoclonal Antibodies and Small Molecule Drugs?

1, Traditional small molecule drugs (1)Tissue penetration: Usually very good; (2)Binding: usually contains distributions; (3)Degradation: Metabolic degradation; (4)Renal elimination: Usually very important; (5)Free concentration: Small molecule drugs thought to play a role; (6)Pharmacokinetics: Usually linear: usually independent of pharmacodynamics. 2, Monoclonal antibody (1)Tissue penetration: Usually weak; (2)Binding: Usually includes clearance; (3)Degradation: Hydrolytic degradation of proteins; (4)Renal elimination: Rare; (5)Free concentration: thought to function + cause immunogenicity; (6)Pharmacokinetics: Usually nonlinear: usually dependent on pharmacodynamics and HAxA.

Question

Accepted Answer

1, Traditional small molecule drugs

(1)Tissue penetration: Usually very good;

(2)Binding: usually contains distributions;

(3)Degradation: Metabolic degradation;

(4)Renal elimination: Usually very important;

(5)Free concentration: Small molecule drugs thought to play a role;

(6)Pharmacokinetics: Usually linear: usually independent of pharmacodynamics.

2, Monoclonal antibody

(1)Tissue penetration: Usually weak;

(2)Binding: Usually includes clearance;

(3)Degradation: Hydrolytic degradation of proteins;

(4)Renal elimination: Rare;

(5)Free concentration: thought to function + cause immunogenicity;

(6)Pharmacokinetics: Usually nonlinear: usually dependent on pharmacodynamics and HAxA.