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FAQs

FAQs
What are the Advantages and Disadvantages of Monoclonal Antibody?
Advantage: High binding affinity; Prolonged Long duration of pharmacokinetic profile
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What is in vitro ADME Study?
PPB(plasma protein-binding):3 concentrations (including effective concentrations),N=3, focusing on concentration dependence and species differences.
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What are Pharmacokinetic challenges of Biotech Drugs?
species differences,analysis methods,basal concentrations,catabolism and elimination,antibody formation administration regimen,binding protein,preparation quality,drug interaction
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What is Preclinical PK Analysis Method
Noncompartmental Analysis (non-compartmental model); Traditional Compartmental PK Model;Population PK Model;
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Advantages and Disadvantages of Ligand Binding Assay
The Main Advantages of LBA:Sensitivity: High ; Quantitation: Cost effective and Fast The Main Disadvantage of LBA:Require good reagent (time) ;​Dilutions, nonlinear, matrix effect, hook effect, etc.
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How to Generate Bispecific Antibody?
The preparation of bispecific antibodies mainly includes the two-hybrid tumor cell method, chemical coupling, recombinant gene preparation, and other methods. Recombinant DNA technology is currently the most used technology for the preparation of BsAb. .
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What are Bispecific Antibodies
Bispecific antibodies (BsAB), also known as bifunctional antibodies, can simultaneously recognize and bind two different antigens and epitopes and block two different signaling pathways to exert their effects.
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Why are Bispecific Antibodies Better?
​The effectiveness of double-target bispecific antibody or single-target double-epitope bispecific antibody may be superior to the combination of two single-target monoclonal antibodies.
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Application of PDX Models
In particular, patient screening and predictive biomarker study in clinical trials of tumor immune-targeted drugs. The efficacy evaluation results of PDX and clinical similarity reached 87% (CDX only 5%).
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Advantages of the PDX Model
There is no in vitro culture process to "screen" tumors;
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