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What is PDXO Model?

PDX-derived organoid or PDXO model is an in vitro model that inherits most of the advantages of PDX models. PDXO model can be established using the same protocol for patient-derived organoid or PDO model development with some adaptive modifications. PDXOs will be embedded in Matrigel for 3D culture and cultivated in growth medium that is enriched with a tailored cocktail of growth factors. Under such conditions, cancer stem cells or CSCs of cancer origin can retain their genomic, phenotypic and structural features while expansion.