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FAQs

What is Preclinical PK Analysis Method

Noncompartmental Analysis (non-compartmental model):

  The simplest and objective, the obtained parameters (t/2Vd, CL, Cmax, Tmax, MRT, AUCo-t. AUCo, etc.) max. meet the IND declaration requirements, cannot be used for prediction and simulation, and are based on linear PK assumptions;

Traditional Compartmental PK Model:

  Relatively simple and easy to use, can be fitted to non-linear PK data, can be used for prediction and simulation, and help experimental design;

Population PK Model:

  More suitable for sparse data and covariate analysis (NONMEM/Monolix).