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FAQs

Types of Bispecific Antibodies

With the development of technology and platform, bispecific antibody-hydrolyzed forms have been developed into more than 100 molecular forms. The whole can be divided into:

Symmetric formats: 

Symmetric bispecific antibodies retain the Fc region and are more similar to natural antibodies but differ in size and structure. These differences may negatively affect the beneficial properties associated with natural antibodies, such as stability and solubility, which may compromise the stability of these bispecific antibodies' physicochemical and/or pharmacokinetic properties. 

Asymmetric formats: 

In this category, most forms used for this antibody generation attempt to preserve the native structure of natural antibodies as much as possible to maintain the associated functional characteristics and good quality attributes so that most of the asymmetric formats of bispecific antibodies are very similar to the natural antibody. They are considered to have the lowest immunogenicity potential. 

Fragment formats: 

Fragment-based bispecific antibodies combine multiple antibody fragments in a single molecule, without Fc region (crystallized fragment, as opposed to antigen-bound fragment Fab), and avoid chain-related problems. The advantages are high yield and low cost; the disadvantages are relatively short half-life. 

In addition, fragment-based bispecific antibodies may have stability and polymerization problems.