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Types of Early DMPK Studies

Protein binding: plasma, brain tissue, microsomal protein, FBS; Erythrocyte /plasma partition ratio

Optimization permeability and transshipment: Caco - 2. MDCK - MDR1 / BCRP, OATs/OCTs/OATPs

In vitro metabolic DDI: P450 inhibited TDI, P450 induced /PXR, metabolic enzyme phenotype.

Metabolic stability: microsomes, S9, hepatocytes, plasma, whole blood 

Metabolite Screening and Identification: in vitro, in vivo, and GSH Trapping 

In vivo PK: rat, mouse, dog, monkey, pig, rabbit box/single administration


Continuous cross/single point blood sampling 

BBB(homogenate /CSF), Tissue distribution excretion (BDC), in vivo DDI (ABT)