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Medicilon's Lead Optimization in Drug Discovery

2016-09-08
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Medicilon’s medicinal chemistry involves the application of a number of specialized disciplinary approaches all focused on the ultimate goal of drug discovery.  Drug target identification and validation, rational (target-based) drug design, structural biology, computational-based drug design, methods development (chemical, biochemical and computational), and “Hit-to-lead” development are all aspects of medicinal chemistry.  The techniques and approaches of chemical biology, synthetic organic chemistry, combinatorial (bio)chemistry, mechanistic enzymology, computational chemistry, chemical genomics and high-throughput screening are all used and applied by medicinal chemists towards drug discovery.

 

Lead Optimization

Medicilon has completed dozens of drug research projects for clients and successfully identified several drug candidates for clinical trials. Our team provides the following services:more details

Target Assessment – Drug Targets
HITs Identification
Lead Optimization
Clinical Candidate Nomination
Computer Aided Drug Design
SAR Study

Lead optimization strategy

From early phase chemistry, through in vitro toxicity screening and metabolism profiling, to establishing in vivo bioavailability; we put facilities and expertise, state-of-the-art equipment and high quality accommodations at your disposal. No “standard” strategy exists that is suitable for the lead optimization of developmental drugs. Therefore,our first focus in assisting you with lead optimization is not to screen a high number of compounds with as many screening studies as possible,but to start designing your most efficient and effective drug screening strategy that addresses major aspects of ADMET.

Lead Optimization

Lead optimization is an operationally diverse stage of the drug discovery process in which the chemical structures of compounds or biologics are modified to improve target specificity and selectivity, plus pharmacodynamic, pharmacokinetic and toxicological properties to produce a preclinical drug candidate. This process requires detailed characterization of lead compound series and lead biologics, including data related to toxicity, efficacy, stability and bioavailability.

Lead optimization (LO) is one of the most expensive and time-consuming stages of the drug development process.  Multiple factors make it more challenging given the need to improve the probability of technical success:

• The number of LO programs running simultaneously
• The number of molecules within each of those programs
• The need for integrated safety and efficacy endpoints
• The need for reproducible, decision-driving data

When you partner with Medicilon, you will work collaboratively with a dedicated team of experts assigned specifically to your project—sharing information,identifying and interpreting findings and providing you with the critical information you need to move forward with a successful candidate while prioritizing your lead optimization pipeline. This strong and productive relationship will continue until our team enables you to achieve your goal: the selection of a successful candidate for further development.

Contact us

Email : marketing@medicilon.com
Tel : +86 021 58591500

Tips : Above is part of Lead Optimization Services and Lead Optimization in Drug Discovery. You can also CONTACT US with any question or enquiry you may have. We will be happy to discuss your needs in detail and design an appropriate plan of action.

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