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Pharmacodynamic research

2020-06-15
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General principles of pharmacodynamic research: random, controlled, repeated

The basic methods of pharmacodynamic research: in vivo test and in vitro test, in which the new drug pharmacodynamic test has been mainly in vivo test, supplemented by in vitro test.

Dosing methods for pharmacodynamic studies: prophylactic, therapeutic, and combined prevention and administration

Medicilon’s Drug Safety Evaluation Service

Choose more than one animal for pharmacodynamic test, and use 2-3 animal models or cell models for each pharmacological effect.

The basic role of drugs

     1. Side effects: other reactions produced by the drug at therapeutic doses that are not related to the purpose of treatment.

     2. Toxic reaction: A harmful pathological reaction that occurs when the dose of the drug is too large, the drug is taken for too long, or the drug accumulates in the body too much.

     3. After-effects: the remaining biological reactions after drug withdrawal

     4. Drug withdrawal reaction: the disease worsens after drug withdrawal

     5. Allergies: also known as allergic reactions

     6. Specific reaction:

Drug dose and effect relationship

     Dose-effect relationship: The pharmacological effect varies in proportion to the dose within a certain range

     Dose response curve

1. Good response relationship: the effect changes in a proportional proportion within a certain range with the change of dose

Dose-effect curve of drug action


Dose-effect curve of drug action

2. Qualitative response

There are four kinds of pharmacological effects: total, none, positive and negative

The main content of the drug action mechanism:

     1. Physical and chemical reaction (acid resistance)

     2. Participate in or interfere with cellular metabolism

     3. Affect the transport of physiological substances (diuretics)

     4. Effect on enzymes

     5. Ion channels acting on cell membranes

     6. Affect accounting metabolism

     7. Affect the immune mechanism

     8. Non-specific effects (general anesthetic)

     9. Receptor mechanism

Pharmacodynamic test content: in vitro pharmacodynamic test, in vivo pharmacodynamic test, mechanism study

Principles of pharmacodynamic testing: first in vivo, then in vitro; first important, then secondary; test plan basis, condition brief; test results, analysis, evaluation

Commonly used experimental animals:

      Mice, rats, guinea pigs, hamsters

      Rabbits, dogs, monkeys, cats, miniature pigs, chickens, etc.

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