Medicilon pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vivo pharmacokinetics. The pharmaceuticals department provides customers with high quality pharmacokinetic services from all small molecules to macromolecules (proteins and antibodies), including in vitro ADME and in vivo pharmacies and Bioanalysis which involved animal species are non-human primates, dogs, mice, rats, rabbits, guinea pigs and so on. The non-primate platform and the use of isotope protein / antibody experimental platform by the Shanghai municipal government was identified as an important laboratory platform.
Medicilon’s pharmacokinetics mainly studies changes in drug metabolism in vivo, including the process of drug absorption, distribution, metabolism and elimination (ADME) in vivo. The purpose of Medicilon is to provide high-quality data and rapid turnover to support the drug development, preclinical research and clinical research. Our ultimate goal is to provide customers with not only the strong effect and less toxic side effects, but also the pharmacokinetic properties of the drug.
Pharmacokinetic Services include: preclinical pharmacokinetics, the use of isotope-labeled pharmacokinetic studies, new drug clinical pre-pharmacokinetic data.
Our pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and Bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and hamster. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai Government.
Available Studies Include: Excretion Studies; Tissue Distribution; Plasma Protein Binding Studies;
Bioanalysis: Advanced Bioanalytical Method Development; Advanced Bioanalytical Method Validation; Pharmacokinetics;
Our pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and Bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody. The animal species involved in our services are non-human primate, canine, mice, rat, rabbit and hamster. Meanwhile, non-human primate experimental platform and isotope platform for protein/antibody are certified by the Shanghai Government.
Available Studies Include: Method Development and Validation (GLP & Non-GLP)
i) Bioanalysis Pharmacokinetics (Tumor bearing rodents, Bioavailability, Crossover studies, Cassette (N in 1) dosing and analysis, effects of gender on pharmacokinetics, BBB penetration); Stability in Vehicles and Plasma; Drug Interaction Studies; in vitro Metabolic Stability; Prediction and Identification of Major Metabolites; Toxicokinetics Analysis; Distribution Studies;
ii) Pharmacokinetics Package for IND Filing: DMPK package for CFDA and FDA IND filing; Chemical Compounds; Traditional Chinese Medicine; Protein; Antibody;
iii) Metabolic Stability Services: CYP Reaction Phenotyping; Microsomal Stability;S9 Stability; Hepatocyte Stability; Plasma Stability; Metabolite Profiling & Identification;
iv) Drug-Drug Interaction Services: Cytochrome P450 and UGT Reaction Phenotyping; Hepatocyte Induction; Cytochrome P450 Inhibition; Time Dependent Inhibition (Single Point);
v) Permeability and Transporter Services: Caco-2 Permeability; P-gp Inhibition; Available Reaction Phenotyping Services Include: Phase I: Cytochrome P450 Enzymes (CYP); Phase II: UDP-glucuronyltransferases (UGT);
vi) Metabolic Stability: Microsomes Stability; Hepatocytes Stability; Plasma Stability;S9 Stability; Protein Binding Services: Plasma Protein Binding; Brain Tissue Binding; Whole Blood Binding; Blood to Plasma Ratio;
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Medicilon’s Metabolite Identification Services
Pharmacokinetic Research Services
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In Vitro Drug Metabolism Studies Services
