Pharmacodynamic Evaluation Model Platform for Inflammatory and Immune Diseases

• Inflammatory immune diseases have gained much attention as the incidence has grown each year. These diseases can affect many parts of the human bodies and reduce quality of life drastically. However, diagnoses can be frustrating and stressful because no one is sure what causes such diseases.
  The preclinical pharmacology department of Medicilon has been active in this field for many years, and has provided a variety of stable and reliable animal models for different targets and pathways for the evaluation of inflammatory immune disease treatments in order to support successful clinical translation.

RA, rheumatoid arthritis

• RA is a chronic and systemic inflammatory autoimmune disease mainly targeting joints. It has a very high disability rate butthe cause of the disease is still unclear.
  Medicilon models that you can choose from:CIA mice/rats ModelsCFA rats Models
  Major Endpoints:
  (1) Foot Volume

  

  △CIA Models & △CFA Models

  (2) Arthritis Index

  

  △CIA Models

  (3) Cytokine Expression

  

  △CFA Models

  Other arthritis models:Carrageenan-induced acute arthritis mice/rats modelsUric acid sodium induced gouty arthritis rats models

EAE, experimental allergic encephalomyelitis

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  Day after immunization: Body weight of the EAE models in male C57BL/6 mice & Clinical score of EAE models in C57BL/6 mice.

Psoriasis

• Psoriasis is a common skin disease that occurs worldwide. It is a disease that is not only closely related to genetics, but is also related to the environment.
  Medicilon has established diverse models that captures key features of psoriasis, including:IL-23 induced hyperplasia of auricle epidermis miceImiquimod induced psoriasis miceVaginal epithelial mitosis miceTale exfoliation mice
  Major Endpoints:
  (1) Skin thickness

  

  △Pathological skin change of Imiquimod induced psoriasis mice

  (2) Ear thickness

  

  △Pathological skin change of IL-23 induced psoriasis mice

  (3) Skin colligation score of mice

  

  △Pathological skin change of Imiquimod induced psoriasis mice

  (4) Pathological skin score

  

  △Imiquimod induced psoriasis & △IL-23 induced psoriasis

  

  

Atopic Dermatitis (AD)

• Atopic dermatitis is a chronic, recurring, inflammatory skin disease, often accompanied by other symptoms such as allergic rhinitis, asthma, eczema, etc. The cause of the disease is not yet clear and there is no cure.
  The disease related models include:DNFB induced chronic dermatitis miceDNFB & OX induced chronic dermatitis micePhorbol ester induced acute eczema miceDNFB induced acute eczema mice
  Skin score

  

  △DNFB induced chronic dermatitis

  Skin thickness

  

  △DNFB induced chronic dermatitis

  

IBD, Inflammatory Bowel Disease

• Inflammatory bowel disease (IBD) is a group of unexplained chronic intestinal inflammatory diseases. Due to the increasing incidence, it has become a common digestive system disease and is refered to as ulcerative colitis and Crohn’s Disease.
  Our IBD models includes:TNBS induced IBD ratsDSS induced IBD mice

  
  

  

  △Colon length of TNBS induced IBD rats models

  

  △Colon weight of DSS induced IBD mice models

Service Cases

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  Targeting IL-23, Medicilon Assists the Development of a Variety of New Drugs for Psoriasis

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FAQs

• What is a JAK inhibitor？

  Small molecule drugs targeting JAKs.

  Various small molecule inhibitors have been developed for autoimmune diseases. Based on their selectivity and different targets, they can be divided into non-selective, selective, and compound categories.

• 所有研究均在同一园区内实验室有序完成，切实保证实验进度和项目沟通的高效性，占据数据获取和评估的行业优越性。