ABOUT
- Inflammatory immune diseases have gained much attention as the incidence has grown bigger each year. The diseases can affect many parts of human bodies and reduce the quality of life drastically. Yet the diagnoses can be frustrating and stressful because no one is sure what causes such diseases.The preclinical pharmacology department of Medicilon has been deeply involved in this field for many years, and has provided a variety of stable and reliable animal models for different targets and pathways for the evaluation of inflammatory immune disease treatments in order for the successful clinical transformation.
RA, rheumatoid arthritis- RA is a chronic and systemic inflammatory autoimmune disease mainly targeting joints. It has a very high disability rate. The cause of the disease is still unclear.Medicilon models that you can choose from:CIA mice/rats ModelsCFA rats ModelsMajor Endpoints:(1) Foot Volume
△CIA Models & △CFA Models
(2) Arthritis Index
△CIA Models
(3) Cytokine Expression
△CFA Models
Other arthritis models:Carrageenan-induced acute arthritis mice/rats modelsUric acid sodium induced gouty arthritis rats models
EAE, experimental allergic encephalomyelitis
Day after immunization: Body weight of the EAE models in male C57BL/6 mice & Clinical score of EAE models in C57BL/6 mice.
Psoriasis- Psoriasis is a common skin disease that occurs worldwide. It is a disease that is not only closely related to genetics, but also obviously related to the environment.Medicilon establishes diverse models that captures key features of psoriasis, including:IL-23 induced hyperplasia of auricle epidermis mice modelsImiquimod induced psoriasis mice modelsVaginal epithelial mitosis mice modelsTale exfoliation mice modelsMajor Endpoints:(1) Skin thickness
△Pathological skin change of Imiquimod induced psoriasis mice
(2) Ear thickness
△Pathological skin change of IL-23 induced psoriasis mice
(3) Skin colligation score of mice
△Pathological skin change of Imiquimod induced psoriasis mice
(4) Pathological skin score
△Imiquimod induced psoriasis & △IL-23 induced psoriasis
AD, atopic dermatitis- Atopic dermatitis is a chronic, recurring, inflammatory skin disease, often accompanied by other symptoms such as allergic rhinitis, asthma, eczema, etc. The cause of the disease is not yet clear and there is no cure.The disease related models include:DNFB induced chronic dermatitis mice modelsDNFB & OX induced chronic dermatitis mice modelsPhorbol ester induced acute eczema mice modelsDNFB induced acute eczema mice modelsSkin score
△DNFB induced chronic dermatitis
Skin thickness
△DNFB induced chronic dermatitis
IBD, Infectious Bursal Disease- Inflammatory bowel disease (IBD) is a group of unexplained chronic intestinal inflammatory diseases. Due to the increasing incidence, it has become a common digestive system disease in our country. It mainly refers to ulcerative colitis and Crohn’s Disease.Our IBD models includes:TNBS induced IBD rats modelsDSS induced IBD mice models
△Colon length of TNBS induced IBD rats models
△Colon weight of DSS induced IBD mice models
