- Cytokines and their receptors play critical roles in biological processes. Dysfunction or dysregulation of cytokines may cause a variety of pathophysiological conditions. Consequently, cytokine profiling and related technologies are essential for biological studies, disease diagnosis, and drug discovery. Current research has shown promising data for cytokine analysis in diagnosing and treating several diseases. However, these cytokines need robust bioanalytical techniques for assessing endogenous and treatment regulated levels in complex study matrices. Bioanalytical methods for assessing cytokines range from singleplex ELISA assays to microplate multiplex and MSD assays. Immunoassays are the most popular method for cytokine expression assays. Each multiplex assay for cytokine detection has its advantages. Understanding the strengths of different multiplex cytokine assays will aid in selecting an ideal platform for all research applications.Flow Cytometry (FACS) Analysis is another effective method to identify and measure cytokines in complex biological matrices. Flow cytometry employs an array of lasers, fluidics, optics, and electronic detectors to measure fluorescence emission and light scatter from cells. The flow cytometer instrument runs the sample through a laser and quantitates the physical properties such as cell size, surface markers, cytotoxicity and granularity of the cells. FACS can be used for intracellular and secreted cytokine analysis. Besides serum and plasma, flow cytometry analysis can include CSF and synovial fluids for cytokine analysis.Biomarkers are quantifiable measurement that can be objectively assessed as an indicator of a biological process, including anatomic, physiologic, biochemical, or molecular parameters. These markers can be associated not only with the presence and severity of specific diseases but also the effects of medical treatments and interventions.Rapid growth in technological capabilities in low-cost emerging economies is presenting new opportunities and challenges for pharmaceutical companies.

Cytokine and Biomarker Detection
Medicilon can provide detection services for cytokines and biomarkers for the majority of pharmaceutical R&D personnel. Its biological analysis department has complete infrastructure and advanced instruments and equipment. It has high-end technology platforms such as flow CBA, MSD and Luminex systems, which can detect various single plex or multiple forms of cytokines and biomarkers.

Flow Cytometry Technology
Medicilon's streaming technology platform is committed to exploring and insight into the progress of tumor immune targeted therapy drugs, and providing accurate and reliable test prediction data in the early development stage. Our team has rich experience in experimental operation, streaming method development and data analysis, and every scientists could be independently responsible for the project. The platform is equipped with powerful flow cytometers of different brands such as BD and Bio-Rad.

Metabolite Identification (MetID) Service
The MetID team of Medicilon is composed of experienced scientists. We provide fast and reliable in vivo and in vitro MetID and reactive metabolite capture services. We also support new drug screening and domestic and foreign IND filings. Since the establishment of MetID team, Medicilon has successfully completed a large number of different types of research projects for the clients, including the challenging peptide MetID research.

Drug Forming Research
Medicipia provides research services for compound druggability evaluation. The evaluation indicators involve in-vitro pharmacokinetic research, bioavailability research, early safety evaluation research, etc., assisting pharmaceutical companies to select candidate compounds with better druggability prospects and carry out further development, or early termination of research and development of drugs with poor druggability prospects.

Safety Assessment Lab of Process Chemistry
In the research and development process of innovative drugs, the chemical process research of drugs plays a pivotal role. During the synthesis process to the scale up process in the laboratory, it is not only about output, but also various errors and risks. Therefore, in the development of innovative drugs, the assessment of the safety of chemical processes and equipment is extremely important.

Process Department Solid Form Screening
The solid screening platform of Medicilon process department strictly complies with the registration regulations and regulatory requirements of China NMPA, FDA and other regulatory authorities, studies and controls the solid morphology of drug molecules in API and preparations, and can formulate the optimal screening strategy according to the material characteristics, including but not limited to crystallization method, solvent selection and ion selection.
Medicilon has been actively developing new technologies platforms over the years, integrating emerging methods of green chemistry into its services, using currently popular photoredox chemistry, electrochemisty, catalyst screening, continuous reactions, etc., to provide our customers with high-quality economic solutions.Learn more
Medicilon's preclinical pharmacology and toxicology research team is equipped with a professional send format conversion team, and has established a send data conversion platform that is fully mature in terms of software, technology, specification and quality, so as to realize accurate data conversion and provide a good environment for electronic data submission. In 2020 alone, it has helped customers complete 14 send data conversion projects, of which 3 new drug projects have obtained clinical licenses from FDA.Learn more