ABOUT
- Drug discovery is the initial stage of drug research and development. Through early research, the genetic functions and targets of target diseases are selected and confirmed, the lead compounds are screened and optimized, and the druggability studies such as early safety screening and drug modification are carried out to obtain druggability candidate compounds.Medicilon’s drug discovery service is divided into two departments: Chemistry and Biology, with chemical and biological laboratories, equipped with SFC, Biacore 8K, microplate reader, LC-MS, HPLC and other instruments, including protein purification labs, cell culture labs, protein crystal labs and drug discovery and screening platforms.Medicilon’s Advantages:Flexible service models, including FTE and FFS, to meet diverse needs and priorities;Innovative technologies to meet novel R&D demands: AI-aided drug design, structure-based drug discovery (SBDD), fragment-based drug discovery (FBDD), DNA-encoded chemical library (DEL) technology, PROTAC, etc.Best overall value: strong expertise and capability, rapid turnaround time, full regulatory compliance;Accumulating a lot of customer cooperation experience: to maintain long -term cooperative relationships with many domestic and foreign large pharmaceutical companies and innovative new drug research and development companies.Well-developed biology sharing service platform: 10+ years of cooperation with Shanghai Synchrotron Radiation Facility (SSRF), protein free rooms, purification rooms, cell culture rooms, and BSL-2 laboratories.
Chimistry Services
• Design of new drug synthesis from chemical targets or protein structure-based drugs derived from high-throughput screening
• Structure-effect relationship study
• Lead compounds determination
• Process optimization of preclinical candidate compounds
• Preparation of special reagents, intermediates and molecular fragments
• Preparation of standards
• Synthesis design and preparation of impurities or metabolites
• Synthesis of stable isotope internal standards
• Synthesis of deuterated compounds
• Synthesis of high quality kilo’s sample
• Preparation process study of target compounds
• Drug impurity analysis
• Method development and methodology verification
• General analytical chemistry services
•Protein degradation technology (PROTAC)
• RNA drug design and synthesis technologies (DEL)
• Bioelectronics isotope technology
• Green chemistry
Structural Biology
• Protein crystallization conditions screening
• Protein-small molecule co-crystallization conditions screening
• Protein crystallization, co-crystallization with ligand
• Three-dimensional structure analysis
• FBDD Service
• Selenomethionine (SeMET) medium
• Cell Level Assays
• Enzyme Level Assays
• In vitro functional assays
• Validated biochemical assays
•Western blot analysis
• Cell migration assays
• Radioisotope analysis (3H， 33P, 32P, 35S, 125I，14C)
Computational Biology & Molecular Modeling
• Structural biology-based drug design
• Molecular Simulation and Virtual Screening
• Drug design of novel structures
• Lead compound optimization design
• Intermolecular interaction force detection/measurement (based on Biacore)
Expression & Purification of Recombinant Proteins
•E.coli Expression System
• Yeast Protein Expression System
• Baculovirus Expression
• Mammalian Cell Protein Expression System
• Recombinant kinase preparation
• Recombinant kinase products
X-ray-based Crystal Structural Biology
• High-throughput-based selection of protein crystals
• Diffraction data collection in protein synchrotron radiation
• Protein-compound co-crystallization
• Analysis of protein crystal structure
Preparation of recombinant kinase
• Various expression systems: insect cell, HEK293 cell and E.coli
•Holoenzyme or kinase
• Inhibitor selection level or structural biological level
• Recombinant kinase product
