ABOUT
- Medicilon’s drug discovery service is divided into two departments: Chemistry and Biology, with chemical and biological laboratories, equipped with SFC, Biacore 8K, microplate reader, LC-MS, HPLC and other instruments, including protein purification labs, cell culture labs, protein crystal labs and drug discovery and screening platforms.
- Medicilon Drug Discovery Summary
Hit Identification & Synthesis
Small molecule
PROTAC
Ab/ADC
Nucleic acid
, etc.
Lead Identification
Identify and optimise lead series/ large molecules via in vitro/in vivo efficacy assays and by establishing drug like candidate properties.
Candidate & Backup Selection
Drive selection of candidates via strong data sets for;
Efficacy PK, ADMET, non GLP toxicity and in vivo PK.
Preclinical IND Enabling
Facilitate access to the clinic via GLP toxicology, safety, DMPK, formulation/process development, small molecule GLP production and stability testing
Clinical Candidate Data for IND
Small Molecule GMP Manufacture
Provide GMP manufacture, CMC assay development and API for clinical trials and market
- Medicilon’s advantages:(1) Flexible service models, including FTE and FFS, to meet diverse needs and priorities;(2) Innovative technologies to meet novel R&D demands including AI-aided drug design, structure-based drug discovery (SBDD), fragment-based drug discovery (FBDD), and PROTAC.(3) Balanced service offering: strong expertise and capability, rapid turnaround time, excellent value and full regulatory compliance;(4) Strong customer relations: we develop long-term effective relationships with many clients including both large and innovative new research and development companies.(5) Well-developed structural biology service platform: We have over 10 years of experience cooperating with Shanghai Synchrotron Radiation Facility (SSRF).
Medicilon works with you to deliver projects from your initial idea to IND and beyond, We provide bespoke and established models to deliver critical data sets.
Medicilon ensures high quality candidates are developed by bringing expertise and critical mass in process development, formulation, in vivo screening and manufacturing into projects at an early stage.
Chemistry Services
• Design of new drug synthesis from chemical targets or protein structure-based drugs derived from high-throughput screening
• Structure-effect relationship study
• Lead compounds determination
• Process optimization of preclinical candidate compounds
• Preparation of special reagents, intermediates and molecular fragments
• Preparation of standards
• Synthesis design and preparation of impurities or metabolites
• Synthesis of stable isotope internal standards
• Synthesis of deuterated compounds
• Synthesis of high quality kg sample
• Preparation process study of target compounds
• Drug impurity analysis
• Method development and methodology verification
• General analytical chemistry services
•Protein degradation technology (PROTAC)
• Bioelectronics isotope technology
• Green chemistry
Biology
• Protein crystallization conditions screening
• Protein-small molecule co-crystallization conditions screening
• Protein crystallization, co-crystallization with ligand
• Three-dimensional structure analysis
• FBDD Service
• Selenomethionine (SeMET) medium
• Cell Level Assays
• Enzyme Level Assays
• In vitro functional assays
• Validated biochemical assays
•Western blot analysis
• Cell migration assays
• Radioisotope analysis (3H， 33P, 32P, 35S, 125I，14C)
Computational Biology & Molecular Modeling
• Structural biology-based drug design
• Molecular Simulation and Virtual Screening
• Drug design of novel structures
• Lead compound optimization design
• Intermolecular interaction force detection/measurement (based on Biacore)
Expression & Purification of Recombinant Proteins
•E.coli Expression System
• Yeast Protein Expression System
• Baculovirus Expression
• Mammalian Cell Protein Expression System
• Recombinant kinase preparation
• Recombinant kinase products
X-ray-based Crystal Structural Biology
• High-throughput-based selection of protein crystals
• Diffraction data collection in protein synchrotron radiation
• Protein-compound co-crystallization
• Analysis of protein crystal structure
Preparation of recombinant kinase
• Various expression systems: insect cell, HEK293 cell and E.coli
•Holoenzyme or kinase
• Inhibitor selection level or structural biological level
• Recombinant kinase product
Videos about "Drug Discovery Services"Empowering global drug discovery and development : Medicilon's International Discovery Service Unit(IDSU)
New approaches applied to drug discovery by the medical community and pharmaceutical industry have a direct impact on the development of improved, novel, and curative therapies for patients. Watch the video about the report of "Medicilon Platform Technologies to Enable Novel Drug Discovery".
Service Cases
To build an integrated AI platform for early drug discovery and evaluation, Medicilon and DP Technology reached a strategic collaboration
Medicilon assists Carephar first potassium-ion-competitive acid blocker "Carenoprazan Tablets" approved for sales in China
