Ophthalmic drug R&D platform

• Medicilon’s preclinical ophthalmic research platform has an experienced team integrating advanced drug delivery technology and analysis methodology. Equipped with state of the art devices, we can provide high-quality and efficient experimental research services, professional registration and application support and project management services for customers with ophthalmic drug development needs.

Special Ophthalmic Drug Delivery

• With the help of the ophthalmic operating microscope, we can apply special methods of fine ophthalmic drug delivery for animal species such as rabbits, dogs, miniature pigs and non-human primates, in addition to conventional ways like eye drops and eye ointment administration, etc. Our special delivery methods include：
  Subretinal Injection under microscopeSuprachoroidal InjectionIntravitreal injection
  

Ophthalmic Drug Pharmacokinetic Research

• Species
  Mice, ratsRabbits (Dutch Belted Rabbits, New Zealand Rabbits)MonkeyDogMini pigs
• Administration Method
  Topical ophthalmic administrationSystemic drug administrationIntracameral injectionIntravitreal injectionSubretinal injectionSuprachoroidal injection
• Sample Collection
  Aqueous humorVitreous humorTear fluidEye tissues such as cornea, conjunctiva, and lensWhole blood
• Detection method
  LC-MS/MSELISAFull platform support for bioanalysis

Complete detection system

• The key for preclinical evaluation of ophthalmic drugs lies in the operation and detection of test articles in experimental animals using appropriate instruments and skilled colleagues. With years of rich practical experience and advanced equipment. Medicion ophthalmology research team has solved many complicated problems of ophthalmic research and provided s high-quality research services for our customers.
  Spectralis HRA + OCT, Germany
  
  SPECTRALIS® HRA + OCT is an ophthalmic imaging platform with the latest scalable module design. We can use this system to help clients complete fundus fluorescein angiography and optical coherence tomography. The test that the system can complete are as follows:
  IR, IF, FAF for common fundus imagingRF for common fundus imagingFluorescein Angiography(FA)Optical Coherence Tomography (OCT)
  
  
  
• RETI-port/scan 21, Germany
  
  The system is applied to detect ophthalmic electrophysiological endpoints, like ERG, VEP, EOG, etc.
  
• Fundus Photographic
  
• Others:
  Medicilon's comprehensive eye detection system also includes slit lamps equipped with digital camera systems, tonometers, fundus lasers, indirect ophthalmoscopes, ophthalmic operating microscopes.
  

Animal models of eye diseases

• Diabetic retinopathy (DR)Choroidal neovascularization (CNV) and Retinal vein occlusion(RVO)Retinal neovascularizationXErophthalmiaAcute ocular inflammation model

Service Cases

• 

  Medicilon and EyeCure reached a strategic collaboration to facilitate the preclinical research and development of ophthalmic cell and gene drugs

                 

  

  Congratulations on the positive phase I clinical results of Raymon Pharma's first Chinese eye drops for the treatment of wAMD

Inquire

• 所有研究均在同一园区内实验室有序完成，切实保证实验进度和项目沟通的高效性，占据数据获取和评估的行业优越性。