Featured Stories

On June 2, 2021, the National Medical Products Administration (NMPA) officially announced that the glucocorticoid drug PA9159 nasal spray was approved for clinical use. The PA9159 developed by Zhejiang Palaatu Pharmaceutical Company (Palaatu) is for seasonal and perennial allergic rhinitis. Class 1 new drug PA9159 for rhinitis In addition, Palaatu plans to submit the clinicalRead more

PROTAC technology has a unique mechanism The PROTAC molecule specifically recognizes and binds to the target protein through the target protein ligand (POI Ligand) at one end and the E3 Ligase through the E3 Ubiquitin Ligase Ligand (E3 Ligase Ligand) at the other end. Forming the POI-PROTAC-E3 Ligase Ternary Complex In this ternary complex, theRead more

Safety assessment lab of process chemistry In the research and development process of innovative drugs, the chemical process research of drugs plays a pivotal role.  During the synthesis process to the scale up process in the laboratory, it is not only about output, but also various errors and risks.  Therefore, in the development of innovativeRead more

Salmonella reverse mutation test. The Ames test is currently the internationally recognized test of choice for detecting the mutagenicity and carcinogenicity of new drugs. This test uses the nature of the histidine auxotrophic mutant (His-) of Salmonella typhimurium to produce revertives. Preliminary screening of the mutagenicity of chemical substances. The study found that the concentrationRead more

The test designed to study the toxicity caused by topical medication is a local toxicity test, which is an important part of toxicology research, including irritation test, allergic test, hemolysis and skin toxicity test. Generally speaking, ointments, drops, lotions, scalp patches, sprays, powders for external use and other dosage forms must be tested for localRead more