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Featured Stories

Home Featured Stories

The impact of antibody targets on ADC pharmacokinetics

By medicilon | Featured Stories | 8 March, 2021 |

Tumor treatment is ushering in the era of ADC drugs. ADC is linked by a powerful cytotoxic payload drug and tumor-targeting antibody by a chemical linker, usually the drug-antibody ratio (DAR) is 3.5-4. The design principle is to directly deliver cytotoxic drugs to the tumor part through antibodies without harming healthy cells. ADC drugs approvedRead more

Medicilon will participate 2021 SOT Virtual Annual Meeting

By medicilon | Medicilon Events | 8 March, 2021 |

Medicilon will exhibit the 2021 SOT Virtual Annual Meeting from March 12-26.  Please visit our virtual booth to meet our VPs, Dr. Frank Wang, Dr. Mingzhu Zhang, Dr. Tao Ye and Sally Tang, for more information on our toxicology services.  We look forward to see you. #Medicilon #Toxicology #DrugDiscovery #SOT2021Read more

The role of pharmacokinetics in the calculation of the initial dose of innovative drugs in the first human trial

By medicilon | Featured Stories | 5 March, 2021 |

Whether the initial dose of the first human trial is reasonable or not is directly related to the success or failure of the trial. When determining the initial dose, it is necessary to comprehensively consider the existing animal efficacy, toxicity and pharmacokinetic research data, and it is necessary to avoid excessive initial doses. It canRead more

Important Concepts and Methods of Pharmacokinetics: Clearance Rate of Drugs

By medicilon | Featured Stories | 5 March, 2021 |

Pharmacokinetics Pharmacokinetics is a branch of pharmacology, which provides a mathematical basis for evaluating the time course of drugs in the body and their effects. Pharmacokinetics can quantify the following processes: drug absorption, distribution, metabolism, and excretion. After the patient takes the drug, these pharmacokinetic processes (commonly called ADME) determine the concentration of the drugRead more

Application of pharmacokinetic - pharmacodynamic modeling

By medicilon | Featured Stories | 4 March, 2021 |

The pharmacokinetic-pharmacodynamics (PK-PD) combined model is an important tool for studying the in vivo process of drugs, the effects of drugs on the body and the relationship between the two, that is, the relationship between dose-concentration and concentration-effect is combined in Research together is more helpful to describe and predict the dose-effect relationship. The useRead more

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Top Posts

  • 14 August, 2017

    Factors Affecting Pharmacokinetics of Drugs

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    Preclinical Drug Development Process

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Shanghai Medicilon Inc.

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  • Home
  • About
    • Medicilon Overview
    • Executive Team
    • CEO Message
    • Corporate Culture
    • Company History
    • Honor
  • Services
    • Integrated Projects
      • Antibody-Drug-Antibody (ADC)
      • Preclinical Research Services
      • IND Filing
      • Bio Drug Development
      • Chemical Drug Development
      • Chemical Compound Druggability Assessment
      • Molecular Imaging & Radiochemistry
      • OINDP Development
      • Preclinical Ophthalmic Research Platform
    • Pharmacology Services
      • Cancer Xenograft Models
      • Orthotopic Models
      • Syngeneic Mouse Models
      • Transgenic Mouse Model
      • Humanized Mouse Model (hPBMCEngrafted)
      • PDX Model
      • Digestive System Models
      • Neurological Disorders Models
      • Metabolic Disease Models
      • Inflammation & Immunological Disease Models
      • Other Disease Models
    • Chemistry Services
      • Medicinal Chemistry Services
      • Synthetic Chemistry
      • Process Development Services
      • Analytical Chemistry
    • Drug Formulation
      • Pre Formulation Development
      • Analytical Development
      • Formulation Development Services
      • Generics Consistency Evaluation
      • Research on Quality Control
      • Clinical Trial Material
      • OINDP Development
    • Biology Services
      • Discovery Biology Services
      • Recombinant Protein Services
      • Computational Biology & Molecular Modeling
      • Crystallization & Structural Determination
      • Kinase Services
      • SeMet Media Sales
    • Bioanalytical Services
      • Large Molecule Bioanalysis
      • Small Molecule Bioanalysis
    • Pharmacokinetic Services
      • In Vivo Assays
      • In Vitro Assays
    • Drug Safety Evaluation
      • Inhalation Toxicity Assessment
  • Customer
    • Customer Reviews
    • New Models of Collaboration
    • Intellectual Property Protection
    • Download Center
  • Careers
  • News
    • Medicilon Events
    • Media Coverage
    • Featured Stories
  • Contact
Medicilon Inc