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Animal Disease Model

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1. What is Animal Disease Models?

    Animal models of human diseases refer to animal experimental objects and related experimental materials established in the process of biomedical research that simulate human diseases.

2. The Significance of Animal Disease Models

(1) Alternative

•Clinically research on trauma, poisoning, tumor, etc. cannot be repeated in human body, and many scientific data must not be collected by causing human to suffer;

•As a substitute for humans, animals can be repeatedly observed under specific experimental conditions designed by humans, and animals can be sacrificed to obtain required animal tissues and organs.

• Risks, hazards and ethical issues arising from human experiments are avoided.

(2) Disease materials with low incidence, long incubation period and long course of disease can be provided

•Clinically hereditary, immune, metabolic and endocrine, blood and other diseases have a low incidence, and can replicate relevant animal models for research.

•Clinically tumors, chronic bronchitis, atherosclerosis and other diseases have a long incubation period and a long course of disease, which can reach decades.

• Diseases with long incubation periods, long duration and low morbidity

(3) Controllable

•Diseases are complex and are related to the patient's age, gender, constitution, heredity, and environment.

• When replicating animal models, animals of the same strain, sex, age, and body weight can be selected, and the microbial control (infection of pathogens) and experimental environment standards are also completely consistent;

• Therefore, other influencing factors can be excluded to make the experimental results more accurate and in-depth. Methodological comparability can be increased.

(4) Convenience

Animal models, as "replicas" of human diseases, can be based on experimental needs: • Samples are easily available • Analytical experiments are simplified.

(5) Conducive to a more comprehensive understanding of the nature of the disease

Animal disease model

3. Classification of Animal Models of Human Diseases

•Classified by cause:

–Spontaneous animal model

–Induced animal model

– Genetically engineered animal model

• System-wide classification

– Basic pathological process of disease: inflammation, tumor, shock

– Animal models of diseases of various systems: cardiovascular, respiratory, digestive, occupational diseases

• Sort by model type

– Whole animals, isolated organs and tissues, cell lines, etc.

4. Factors Affecting the Quality of Disease Models

1. The effect of model-causing factors on the replication of animal models;

2. The influence of animal factors on the replication of animal models (standardized experimental animals for wild animals and domestic animals);

3. The influence of experimental technical factors on the replication of animal models;

4. The influence of environmental factors and nutritional factors on replicating animal models.

5. Design Principles of Animal Disease Models

•(1) Similarity and comparability

•(2) Repeatability

•(3) Reliability

•(4) Applicability and controllability

•(5) Ease of operation and economy

6. Precautions for Disease Animal Models

• No animal model can completely replicate human disease, and the correctness of model experiment conclusions is only relative, and must ultimately be verified in humans.

• Keep the model animal as minimal as possible and with the least disturbance;

• The advanced degree of animal evolution does not mean that all organs and functions are close to the degree of human beings; inbred animals cannot be used blindly;

• Search literature and consult whether animals and conditions required for animal experiments are feasible, understand the experience accumulated by predecessors, and avoid waste of human and material resources caused by low-level repetition or blind movement without scientific basis.

The following is the animal model of Medicilon human diseases compiled by the editor for you. For the latest model information, please contact us.

Tumor disease model

      Medicilon provides a variety of effective animal models to test the effectiveness of drugs according to customer needs. Experimental animals include non-human primates, dogs, mice, rats, rabbits, guinea pigs, nude mice and other species. At present, we have established a number of effective animal tumor models, which have been verified by various parties and tested in long-term practice. At the same time, our staff's rich experience and solid theoretical foundation can flexibly develop and establish various customized tumor disease models according to customer's customized requirements to meet customer needs. See more.

Cancer TypeCell Line
Breast cancerBT-474,HCC1569,HCC1954,HCC70,JIMT-1,MCF-7,MDA-MB-231,MDA-MB-468,MX-1,SUM149PT,ZR-75-1,HCC1806
Colon cancerCOLO 205,DLD-1,HCT 116,HCT-15,HT-29,LIM-1215,LOVO,LS 174T,NCI-H508,RKO,SW480,SW620
EndometriumAN3 CA,HEC-1-A
GlioblastomaU-87MG,U-87 MG-Red-Fluc(PE),LN-229
Thyroid gland medullaryTT
HepatocellularHep G2,HuH-7
LymphomaSU-DHL-4,DB,SU-DHL-6,Mino,Daudi,Jeko-1,Raji,TMD-8,WSU DLCL2,DOHH2,OCI-LY19,OCI-LY10,MM.1S,RPMI-8226,OPM2
PancreaticAsPC-1,Bx PC-3,Capan-1,Capan-2,CFPAC-1,HPAF-II ,MIA PaCa-2,PANC-1,SU.86.86
ProstateDU 145,PC-3
Urinary BladderRT4

Digestive System Disease Model     

Medicilon provides various effective animal models (renal failure model, anemia animal model, gastric acid secretion animal model, gastric ulcer model, etc.) according to the needs of customers to test the effectiveness of drugs. Conventional digestive system diseases include: gastric acid secretion, gastric ulcer, renal failure, etc., animal experiments are carried out through rats. See more.

Renal failureNephrectomy (5/6)Rats
AnaemiaRenal failure-inducedRats
Iron deficiency anemiaRats
Gastric acid secretionsPylori ligationRats
Gastric ulcerEthanol-inducedRats
Non-steroidal anti-inflammatory drug-induced modelsRats
Cold water stress-inducedRats
Chronic, acetic acid-inducedRats
Reflux esophagitis-inducedRat
Ulcerative colitis (UC)Trinitrobenzene sulfonic acid (TNBS)-inducedRats
Dextran sulfate sodium (DSS)-inducedRats/mice

Endocrine and Metabolic Disease Models

Medicilon provides a variety of effective endocrine disease models and metabolic disease animal models to test the effectiveness of drugs according to customer needs. Conventional endocrine diseases and metabolic diseases include: diabetes, obesity, dyslipidemia, etc. Animal experiments are carried out through rats, hamsters, etc. See more.

Obesity and diabetesStreptozotocin-inducedRats/mice
SpontaneousMice (db/db, ob/ob)
SpontaneousZDF rats
High-fat and high-sugar diet-inducedMice
HyperuricemiaPotassium oxonate-inducedRats/mice
Adenine- and ethambutol-inducedRats
Liver fibrosisBile duct ligationRats
Composite factor method-inducedRats
Porcine serum-inducedRats
Lipid abnormalityHigh fat/cholesterol/fructose diet-inducedHamster
Hereditary atherosclerosis (APOE mice + high-fat diet)APOE mice
Non-alcoholic fatty liver (NAFLD, NAFL, NASH)Hereditary atherosclerosis (APOE mice)APOE mice
Non-alcoholic fatty liverRats
High-fat diet (HFD)Rats/mice, hamsters
Methionine- and choline-deficient diet (MCD)Mice
Composite factor-inducedRats
ThrombusArteriovenous bypass thrombosisRats/mice
Carrageenan-induced tail vein thrombosisMice
Deep vein thrombosisRats
Carotid artery thrombosisRats/mice

Inflammatory and Immune Disease Models

Medicilon provides a variety of effective inflammatory disease models and immune disease animal models according to customer needs to test the effectiveness of drugs. Conventional inflammatory and immune diseases include: acute inflammation, arthritis, experimental allergic encephalomyelitis, etc. Animal experiments are carried out in rats and mice. See more.

DiseasesInflammatory and Immunological Disease ModelsAnimals
ArthritisChronic infectious arthritis (CIA)Mice/rats
Adjuvant induced-arthritis (AIA)Rats
Pristane-induced arthritis (PIA)Rats
Carrageenan-induced arthritisRats
Experimental allergic encephalomyelitis (EAE)Mice
PsoriasisEstrogen-induced vaginal epithelium mitosisMice
Tail scalesMice
IL-23-induced auricle epidermal dysplasiaMice
Propranolol-inducedGuinea pigs
Atopic dermatitis and eczemaDinitrofluorobenzene (DNFB)-inducedMice
Dinitrochlorbenzene + OX-inducedMice
Phorbol ester-inducedMice
Acute inflammationToe swellingRats/mice
Auricle swellingMice
Capillary permeability testRats/mice
Granuloma proliferationRats

Nervous System Disease Models

Medicilon provides various effective animal models (depression animal model, Parkinson's disease animal model, psychotic animal model, etc.) according to the needs of customers to test the effectiveness of drugs. Conventional neurological diseases include: mental illness, Parkinson's disease, depression, pain (central), etc., through animal experiments such as rats and guinea pigs. See more.

DiseasesNervous System Disease ModelsAnimals
Anti-depressantInhibition of 5-HT, NA and DA brain synaptosome uptake (sample selection and IC 50 Determination)Rats
Forced swimming test (rats/mice, Noduls, video analysis)Rats/mice
Tail suspension test (mice, Noduls, video analysis)Mice
5-HTP-induced head twitch potentiationMice
Reserpine-induced ptosisMice
Yohimbine toxicity enhancement testMice
High-dose apomorphine antagonismMice
Chronic mild unpredictable stimulation (CUMS) in ratsRats
New environment eating inhibition testRats/mice
MAO-A, MAO-B activity testMice
Protective effects on hippocampal neurons of newborn rats
(glutamate injury, hydrogen peroxide injury, glucose and hypoxia injury, and dexamethasone injury, among others)
Newborn rats
Effect on synthesis and secretion of BDNF in SH-SY5Y cellsSH-SY5Y cells
Anticonvulsant testYohimbine toxicity enhancement testMice
Pentylenetetrazole-induced seizureMice
Dicentime-induced seizureMice
Picrotoxin-induced seizureMice
Sedative-hypnotic and anti-anxiety testsSynergistic effect with pentobarbital drugsMice
Effect on subthreshold hypnotic dose of barbitalMice
Re-sleep testMice
Open field test (rats/mice, camera monitoring and software processing for whole process)Rats/mice
Elevated plus maze testRats
Shuttle box test (full camera monitoring and software processing)Rats
Pain (with Von Frey hairs test)Hot plate testRats/mice
Tail-flick testRats/mice
Heat radiation testRats/mice
Tenderness testRats/mice
Von Frey hairsRats/mice
Acetic acid-induced writhing testMice
Formalin-induced testRats/mice
CFA-induced painRats/mice
Carrageenan-induced painRats/mice
LPS-induced painRats/mice
Selective spinal nerve ligation (L5/L6)Rats/mice
Sciatic nerve injuries (SNI)Rats/mice
Pain induced by diabetes, incision, and cancerRats/mice
Anti-dementia testsAcquired memory impairment (6-channel video analysis of the step-down test)Mice
Memory consolidation impairment (6-channel video analysis of the step-down test)Mice
Memory retrieval impairment (6-channel video analysis of the step-down test)Mice
Light-dark transition testing (4-channel video analysis)Mice
Acquired memory impairment (Morris water maze video analysis)Rats
Acetylcholinesterase ActivityMice
New object recognition testingRats
APP/PS1 (Morris water maze, Cognition Wall)Transgenic mice
In vitro testingCell level, molecular biology
Anti-schizophreniaMK801-induced schizophrenia with positive symptomsMice
MK801-induced schizophrenia with negative symptomsMice
Ketamine-induced schizophrenia with negative symptomsMice
Lower lip retractionRats
Phencyclidine-induced activity enhancementRats

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