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LC-MS/MS Method Development

2018-01-17
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What Is LC-MS?

(LC) Liquid Chromatography:

Chromatography is a separations method that relies on differences in partitioning behavior between a flowing mobile phase and a stationary phase to separate the the components in a mixture.
A column holds the stationary phase and the mobile phase carries the sample through it.
Sample components that partition strongly into the stationary phase spend a greater amount of time in the column and are separated from components that stay predominantly in the mobile phase and pass through the column faster.

(MS) Mass Spectrometry:

Mass spectrometers use the difference in mass-to-charge ratio (m/z) of ionized compounds to separate them from each other.

Compounds have distinctive fragmentation patterns that provide structural information to specifically detect compounds.

(MS) Mass Spectrometry

Types of Mass Spectrometers

• LC-MS (Single Quadrupole)
LC-MS/MS (Triple Quadrupoles)
• LC-Q (Ion Traps, Linear Ion Traps)
• LC-Q-TRAPS (Quadrupole Linear Ion Traps)
• LC-TOF-MS (Time-of-Flight)
• MALDI-TOF-MS
• Q-TOF-MS (Quadrupole Time-of-Flight)
• FT-MS (Fourier Transform)
• Others

LC/MS/MS Method Development & Validation

Quick turnaround time to speed up the drug development process 

Chemical Analytical Center of Medicilon provides general analysis and purification services for the clients. Our experts have rich experience and proficient skills to solve problems, which are highly appreciated by clients.

General Analytical Chemistry Services

  • NMR 1D、2D(H-NMR、C-NMR、P-NMR、F-NMR、HSQC、HMBC、COSY、NOESY, et al)

  • LC-MS Analysis

  • HPLC Analysis (including ELSD)

  • Chiral HPLC Analysis

  • General LCMS Testing (ROI、LOD、Cl-、SO42-、mp、HM、Specific Rotation、Water Content, et al)

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LC-MS Analysis Service

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