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Top 10 Global Clinical Research Organizations in 2021| ADC, precision and deep cultivation for targeted drug delivery| What are the three major in vitro pharmacokinetic research methods?
Oct 12,2021
Types and Analysis of Residual Solvents in the R&D and Production of APIs
Residual solvents in drugs are defined in Q3C as organic volatile compounds produced or used in the production of bulk drugs or excipients, and during the preparation of the formulations, and they cannot be completely eliminated in the process. In the process of drug substance impurity analysis, the study of residual solvents has attracted muchRead more
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Oct 12,2021
The Selection and Quality Control of the Starting Materials of API
Pharmaceutical preparations are composed of three major elements: qualified raw materials, appropriate amounts of excipients, and scientific production technology. Among them, the quality of raw materials is the first element that affects pharmaceutical preparations. Pharmaceutical outsourcing process institutions can provide outsourcing process R&D and production of intermediates, bulk drugs, preparations, etc. Starting materials are anRead more
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The Selection and Quality Control of the Starting Materials of API
Oct 12,2021
Major Characteristics of the API Production Process
Compared with the production of pharmaceutical preparations, the production process of API drugs has its own characteristics. Because the production process of APIs often includes complex chemical and biological changes, and has a relatively complex intermediate control process, by-products are often produced during the production process, which usually requires a purification process. At present, manyRead more
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Oct 12,2021
Understand Whether the Structure of the Synthetic API is Correct
The preparation and research of APIs is at a critical position in the chemical drug R&D process, and the structure of the prepared compounds is consistent to ensure that subsequent quality control studies, pharmacology and toxicology studies, and clinical studies are meaningful. Through the structure of the synthesized APIs Confirmation can characterize whether the structureRead more
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Oct 12,2021
Caco-2 Cell Model of ADME Model in Vitro
The new drug development stage includes 4 important stages: target determination, model establishment, lead compound discovery, and lead compound optimization. After the target is determined, a biological model such as an in vitro ADME model of a drug should be established, which is mainly used to study drug absorption, distribution, metabolism and drug toxicity, inRead more
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Oct 11,2021
Nine Development Trends of Chemical Synthetic Drugs
As an important part of drug research and development, chemically synthesized drugs are still the subject of new drug research and development for major pharmaceutical companies in the world today. The production of chemical drugs is inseparable from three stages: raw material pretreatment, chemical reaction and product refinement. Chemical drugs can be inorganic minerals orRead more
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Oct 11,2021
Six Directions of Chemical Synthesis Drug Research and Development
As an important part of the development of the pharmaceutical industry, chemically synthesized drugs are the main source of drug candidates, as well as a high-input, high-output and high-efficiency work. The main directions for chemical synthesis drug research and development are as follows. Research and Develop New Chemical Entity Drugs New Chemical Entities (NCE) drugsRead more
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Oct 11,2021
Medicilon Intermediate Synthesis Service
As a provider of global chemical services, Medicilon has a strong analytical chemistry team to support synthetic chemistry services. We are committed to providing customers with the highest quality and most valuable products and services through prolific, fast, problem-solving and active communication. Our team has received excellent professional training, keeps close contact and interaction withRead more
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Oct 09,2021
Transformation of Medicilon's New Drug R&D Data in SEND Format to Help You Successfully Apply for FDA
Domestically Made Innovative Drugs Have Gained World Attention In recent years, China's pharmaceutical industry has developed rapidly. With the encouragement and support of national policies, the research and development of new and generic drugs in China has grown significantly.  With this momentum of development, Medicilon's pharmaceutical R&D has not only brought about earth-shaking changes toRead more
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Oct 08,2021
Choose mouse model for Tumor Immunotherapy Research
The direction of tumor immunity is undoubtedly one of the most popular directions in the field of cancer research today, but for researchers who are new to this field, the results of using only the mouse tumor model used in the previous tumor research will not be convincing. For example, The most common human tumorRead more
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