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Top 10 Global Clinical Research Organizations in 2021| Top 10 Global CDMO Enterprises| Preclinical Drug Development Process
Oct 26,2021
Common Protein Expression System
Introduction In vitro recombinant protein production is a protein obtained by applying recombinant DNA or recombinant RNA technology. Catalog The use of in vitro protein expression technology to extensively produce various types of recombinant proteins, which are used in the fields of medicine, food, daily chemical and other fields. The following briefly introduces the mainRead more
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Oct 26,2021
Application of Baculovirus-insect Cell Expression System
Introduction to Bac-to-Bac System The baculovirus-insect cell system is a binary system consisting of two parts. The first part is the baculovirus expression vector, which is an insect virus whose function is obviously to introduce the foreign gene encoding the target protein into the host cell. Another function of baculovirus expression vectors is to provideRead more
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Oct 26,2021
Comparison of E. coli and Insect Baculovirus Expression Systems
Principle of Escherichia coli Expression System The Escherichia coli expression system is an expression system that efficiently expresses genes encoding protective antigens of pathogenic microorganisms in Escherichia coli through DNA recombination technology. It is currently the most commonly used system for recombinant protein expression. The E. coli expression system has been studied earlier and hasRead more
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Oct 25,2021
Baculovirus Expression Vector System and its Application
The most researched insect baculovirus is Autographa californica multiple nuclear polyhedrosisvirus (AcMNPV), its host is Spodoptera frugiperda (Sf); Bombyx mori nuclear polyhedrosis virus (Bombyx) mori nuclear polyhedrosis virus (BmNPV), whose host is the silkworm (Bombyx mori), these two baculovirus vectors are often used to express foreign proteins [2,3]. The gene expression of baculovirus is dividedRead more
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Oct 25,2021
What is Baculovirus Expression System and its Advantages
What is Baculovirus Expression System Baculovirus belongs to the Baculoviridae family (Baculoviridae), which is divided into nuclear polyhedrosis virus and granulovirus. The virus particles are rod-shaped and are a type of DNA virus that specifically infects arthropods and has an envelope. Genomic DNA is compressed and packed in a rod-shaped capsid in a super-coiled form,Read more
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What is Baculovirus Expression System and its Advantages
Oct 22,2021
What is an API Drugs?
What is an API Drugs? API drugs refer to the raw materials used in the production of various preparations. They are the effective ingredients in the preparations. Various powders, crystals, extracts, etc., prepared by chemical synthesis, plant extraction or biotechnology, are used for medicinal purposes. Substances taken directly. APIs, also known as active ingredients ofRead more
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Oct 22,2021
What is the Difference Between Genuine Drugs, Generic Drugs, and APIs?
Genuine Drug-What is a Genuine Drug? Genuine medicine is a concept unique to China, and it is called original research drug in European and American countries. It refers to the original research and development of new drugs, which have been approved for listing after tens of thousands of compounds and rigorous clinical trials. It takesRead more
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Oct 21,2021
Development and Verification of Analysis Methods for Disposable Systems
The dissolution/precipitate evaluation is an important part of the process-specific verification of filters and disposable systems in the pharmaceutical field to examine the applicability of equipment (including filters and disposable systems) in specific processes. This article describes the development and validation of the dissolution/precipitate analysis method for the verification test of the dissolution/precipitate, and introducesRead more
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Oct 21,2021
HPLC Analysis Method Development and Verification System
Analytical method development The development of analytical methods mainly includes the selection of chromatographic columns, the selection of mobile phases, the selection of detection wavelengths, and the optimization of gradients. At present, HPLC is mostly used in reversed phase, so this article mainly uses reversed phase as an example to explain. Selection of Column TheRead more
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Oct 21,2021
Summary of the Development and Verification of Analytical Methods for Stability Indicators in New Drug Research
In the Non-Clinical stage of new drug development, why develop methods with stability indicators? What is the difference between the non-Clinical stage degradation test and the later stage? What precautions need to be considered? Have the difficult problems in method validation trouble you for a long time? Drug Non-clinical Research and Stability Indication Method Non-clinicalRead more
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