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Top 10 Global Clinical Research Organizations in 2021| Top 10 Global CDMO Enterprises| Preclinical Drug Development Process
Oct 21,2021
To What Extent can the Calculation of ADMET of Candidate Drugs be Predicted?
The discovery and development of new drugs is expensive & time-consuming! Whether a candidate can become a medicine is a work that R&D personnel continue to explore! When a molecule has obtained the desired drug effect, the work of preparing the drug begins to spread, and the research work of “absorption-distribution-metabolism-excretion-toxicity” (ie ADMET) is alsoRead more
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Oct 21,2021
How a Pill Accomplishes its Mission in the Body-ADME
Drugs enter the body through the four processes of absorption, distribution, metabolism, and excretion, but the four processes of different administration routes have their own advantages. Today we talk about the most common oral drug absorption and metabolism processes in the digestive tract. After oral administration of the drug in the gastrointestinal tract, it entersRead more
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Oct 14,2021
Talking about Pharmacokinetics PK
Pharmacokinetics (pharmacokinetics, PK) and pharmacodynamics (pharmacodynamics, PD), in fact, can be described as key research content, the two complement each other and are indispensable. PK refers to the quantitative study of the changes in the in vivo processes such as absorption (A), distribution (Distribution, D), metabolism (Metabolism, M) and excretion (Excretion, E) of drugs inRead more
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Talking about Pharmacokinetics PK
Oct 14,2021
What are the Procedures for DMPK?
The DMPK study of the new drug in the corresponding patient, including the pharmacokinetic study of a single dose or/and multiple doses; If the new drug is a prodrug or a drug that is mainly eliminated in the human body by metabolism, the metabolic pathway, metabolic structure and pharmacokinetics of the new drug need toRead more
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Oct 14,2021
What are the DMPK Parameters?
DMPK Parameters: Peak drug concentration (Cmax) The highest blood drug concentration after administration. This parameter is an important indicator reflecting the absorption rate and degree of absorption of drugs in the body.Peak time (Tmax)    the time required to reach the peak concentration of the drug after administration. This parameter reflects the rate at which theRead more
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Oct 13,2021
Key Material Attributes of API Particle Size in Formulation Development
The particle size of the API, as a key material attribute in the development of formulations, not only affects the powder properties of the API (such as fluidity), the uniformity of the formulation content, the chemical stability of the API and the formulation, but also affects the dissolution of the formulation, which in turn affectsRead more
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Oct 13,2021
What are APIs, Original Research Drugs and Generic Drugs?
The bulk drug is a kind of compound, because it is impossible for the compound to have perfect physical and chemical parameters to achieve the greatest effect in the complex environment of the human body, so the regular original research drug needs to use various excipients and dosage forms to achieve the curative effect. ChemicalRead more
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Oct 13,2021
Analysis of the Difference Between Intermediates and APIs
Intermediates refer to intermediate products in the process of compound synthesis. Pharmaceutical intermediates are some chemical APIs or chemical products used in the synthesis process of APIs. They do not require a production license for APIs and can be produced in ordinary chemical plants. , As long as it reaches a certain level, it canRead more
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Oct 13,2021
Four Processes for the Production of API
APIs are the prerequisite for the production of pharmaceutical preparations. In all links of the pharmaceutical industry chain, they play the role of processing and manufacturing basic pharmaceutical industry APIs, and most of them are outsourced production. API drug outsourcing process services refer to pharmaceutical companies entrusting other pharmaceutical R&D institutions to conduct API outsourcingRead more
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Oct 12,2021
Types and Analysis of Residual Solvents in the R&D and Production of APIs
Residual solvents in drugs are defined in Q3C as organic volatile compounds produced or used in the production of bulk drugs or excipients, and during the preparation of the formulations, and they cannot be completely eliminated in the process. In the process of drug substance impurity analysis, the study of residual solvents has attracted muchRead more
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