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Top 10 Global Clinical Research Organizations in 2021| Medicilon Pharmacokinetic Services for First-in-Class Ubiquitination Inhibitor Development| ADC, precision and deep cultivation for targeted drug delivery
Oct 12,2021
Caco-2 Cell Model of ADME Model in Vitro
The new drug development stage includes 4 important stages: target determination, model establishment, lead compound discovery, and lead compound optimization. After the target is determined, a biological model such as an in vitro ADME model of a drug should be established, which is mainly used to study drug absorption, distribution, metabolism and drug toxicity,
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Caco-2 Cell Model of ADME Model in Vitro
Oct 11,2021
Nine Development Trends of Chemical Synthetic Drugs
As an important part of drug research and development, chemically synthesized drugs are still the subject of new drug research and development for major pharmaceutical companies in the world today. The production of chemical drugs is inseparable from three stages: raw material pretreatment, chemical reaction and product refinement. Chemical drugs can be inorganic minerals orRead more
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Oct 11,2021
Six Directions of Chemical Synthesis Drug Research and Development
As an important part of the development of the pharmaceutical industry, chemically synthesized drugs are the main source of drug candidates, as well as a high-input, high-output and high-efficiency work. The main directions for chemical synthesis drug research and development are as follows. Research and Develop New Chemical Entity Drugs New Chemical Entities (NCE) drugsRead more
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Oct 11,2021
Medicilon Intermediate Synthesis Service
As a provider of global chemical services, Medicilon has a strong analytical chemistry team to support synthetic chemistry services. We are committed to providing customers with the highest quality and most valuable products and services through prolific, fast, problem-solving and active communication. Our team has received excellent professional training, keeps close contact and interaction withRead more
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Oct 09,2021
Transformation of Medicilon's New Drug R&D Data in SEND Format to Help You Successfully Apply for FDA
Domestically Made Innovative Drugs Have Gained World Attention In recent years, China's pharmaceutical industry has developed rapidly. With the encouragement and support of national policies, the research and development of new and generic drugs in China has grown significantly.  With this momentum of development, Medicilon's pharmaceutical R&D has not only brought about earth-shaking changes toRead more
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Transformation of Medicilon's New Drug R&D Data in SEND Format to Help You Successfully Apply for FDA
Oct 08,2021
Choose mouse model for Tumor Immunotherapy Research
The direction of tumor immunity is undoubtedly one of the most popular directions in the field of cancer research today, but for researchers who are new to this field, the results of using only the mouse tumor model used in the previous tumor research will not be convincing. For example, The most common human tumorRead more
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Oct 08,2021
What is a Syngeneic Tumor Mouse Model?
The syngeneic tumor mouse model is one of the earliest tumor animal models, and it has a history of at least 50 years. This type of model is to transplant tumor cells or tissues derived from mice into host mice with the same genetic background and immune capabilities. The allograft (ie, tumor) formed in theRead more
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What is a Syngeneic Tumor Mouse Model?
Sep 29,2021
Integrated Preclinical Trials Services
COMPANY PROFILE Shanghai Medicilon Inc. is one of the top contract research organizations (CRO) in China. Since its establishment in 2004, Medicilon has been striving to offer fully integrated pharmaceutical services for the global scientific community. We have over 1,900 employees cross biology, chemistry and preclinical research. Over 30% of our employees have M.S. andRead more
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Integrated Preclinical Trials Services
Sep 28,2021
Improving Oral Bioavailability of Poorly Water-soluble Drugs
In the past decade, the discovery of poorly soluble drugs has prompted a continuous need to develop a new dosage form to increase the solubility of these drugs. They increase the solubility of the drug in the gastrointestinal tract by increasing the dissolution rate of the drug in the gastrointestinal tract, thereby promoting the absorptionRead more
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Improving Oral Bioavailability of Poorly Water-soluble Drugs
Sep 28,2021
Asarone Pharmacokinetics and Bioavailability Test
Asarone is based on a-asarone (2,4,5-trimethoxy-1-alkenylbenzene, also known as a-Asarone), the main active ingredient in the traditional Chinese medicine Acorus calamus. It is artificially synthesized to relieve cough and asthma. Anti-epileptic drugs. Since the blood concentration of the drug after entering the human body is very low, it is difficult to carry out pharmacokinetic studiesRead more
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Asarone Pharmacokinetics and Bioavailability Test