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Top 10 Global Clinical Research Organizations in 2021| ADC, precision and deep cultivation for targeted drug delivery| What are the three major in vitro pharmacokinetic research methods?
Oct 08,2021
What is a Syngeneic Tumor Mouse Model?
The syngeneic tumor mouse model is one of the earliest tumor animal models, and it has a history of at least 50 years. This type of model is to transplant tumor cells or tissues derived from mice into host mice with the same genetic background and immune capabilities. The allograft (ie, tumor) formed in theRead more
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What is a Syngeneic Tumor Mouse Model?
Sep 29,2021
Integrated Preclinical Trials Services
COMPANY PROFILE Shanghai Medicilon Inc. is one of the top contract research organizations (CRO) in China. Since its establishment in 2004, Medicilon has been striving to offer fully integrated pharmaceutical services for the global scientific community. We have over 1,900 employees cross biology, chemistry and preclinical research. Over 30% of our employees have M.S. andRead more
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Integrated Preclinical Trials Services
Sep 28,2021
Improving Oral Bioavailability of Poorly Water-soluble Drugs
In the past decade, the discovery of poorly soluble drugs has prompted a continuous need to develop a new dosage form to increase the solubility of these drugs. They increase the solubility of the drug in the gastrointestinal tract by increasing the dissolution rate of the drug in the gastrointestinal tract, thereby promoting the absorptionRead more
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Improving Oral Bioavailability of Poorly Water-soluble Drugs
Sep 28,2021
Asaron Pharmacokinetics and Bioavailability Test
Asarone is based on a-asarone (2,4,5-trimethoxy-1-alkenylbenzene, also known as a-Asarone), the main active ingredient in the traditional Chinese medicine Acorus calamus. It is artificially synthesized to relieve cough and asthma. Anti-epileptic drugs. Since the blood concentration of the drug after entering the human body is very low, it is difficult to carry out pharmacokinetic studiesRead more
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Asaron Pharmacokinetics and Bioavailability Test
Sep 28,2021
Bioavailability of Different Dosage Forms of Glimepiride
Glimepiride belongs to the third generation of sulfonylureas and is widely used clinically in the treatment of type 2 diabetes. Tablets and pills are common dosage forms of glimepiride. Using in vitro dissolution tests to determine the bioavailability of glimepiride tablets and dropping pills can evaluate the quality of glimepiride in different dosage forms producedRead more
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Bioavailability of Different Dosage Forms of Glimepiride
Sep 27,2021
The Effect of Particle Size on Drug Bioavailability
Controlling the particle size of a drug is a key part of drug preparation. The size of the drug particle size can directly affect the solubility and dissolution rate of the drug, thereby affecting the clinical efficacy. For example, in the development of solid preparations, reducing the particle size of drug particles can significantly increaseRead more
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Sep 26,2021
What is Pre-IND Meeting FDA?
Before the sponsor submits the IND application, the sponsor can request a Pre-IND meeting FDA with the review leader. The main purpose of the meeting is to evaluate and reach consensus on the design of animal research needed to support the first human trial, which can speed up the development of new drugs, effectively shorten.
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What is Pre-IND Meeting FDA?
Sep 26,2021
The United States Exempts the IND's BA/BE Safety Report Requirements
BA/BE Exempted From IND Requirements Not all BA/BEs meet the requirements of IND exemption (that is, there is no need to submit an IND application and perform clinical trials in accordance with IND requirements). For example, BA/BE involving cytotoxic drugs does not meet the requirements of IND exemption. The guidelines followed by the US INDRead more
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The United States Exempts the IND's BA/BE Safety Report Requirements
Sep 24,2021
Acute Toxicity Test/Detection/Evaluation
Acute Toxicity Test / Repeated Dosing Screening Test Acute toxicity evaluation is one of the basic types of in vivo safety evaluation. Drug registration often requires acute toxicity evaluation. Acute toxicity test data has a special role in safety evaluation, and MTD or MFD can be determined in the initial toxicity description. The data obtainedRead more
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Acute Toxicity Test/Detection/Evaluation
Sep 23,2021
Medicilon-Your Ideal DMPK Research Partner
The research and development of innovative drugs is a long-term process with high investment, high risk and high return. It takes more than ten years on average from early discovery to successful listing, and the cost is as high as more than 1 billion US dollars. Pharmacokinetics (DMPK) research runs through all stages of leadRead more
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Medicilon-Your Ideal DMPK Research Partner