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Top 10 Global Clinical Research Organizations in 2021| ADC, precision and deep cultivation for targeted drug delivery| What are the three major in vitro pharmacokinetic research methods?
Sep 17,2021
Medicilon Cytotoxicity Test Service
The Biology Department of Shanghai Medicilon has extensive experience in the field of in vitro biology, through enzyme level determination, cell level determination, cell biology, biochemistry, in vitro isotope determination, stable cell line establishment, gene knockout, RNAi and MicroRNA Technology, etc., to provide a complete set of biological services. Cytotoxicity test Medicilon Cell Level MeasurementRead more
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Medicilon Cytotoxicity Test Service
Sep 16,2021
Application of Stable Isotope-Labeled Drugs in Clinical Pharmacokinetic Research
Clinical pharmacokinetics (Clinical Phamacokinetics) research has revealed the mystery of the fate of many drugs in the body, and has enriched the knowledge of human clinical rational use of drugs. It undoubtedly plays an important guiding role in avoiding the occurrence of adverse drug reactions and improving the level of drug treatment.
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Application of Stable Isotope-Labeled Drugs in Clinical Pharmacokinetic Research
Sep 15,2021
The Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies and Their Application in Disease Treatment
Therapeutic monoclonal antibodies are currently one of the hotspots in the development of new drugs. Compared with traditional small molecule drugs, their pharmacokinetic characteristics and formation mechanisms are very different. A full understanding of these mechanisms and characteristics can effectively guide Screening and development of monoclonal antibody drugs. Monoclonal antibody drugs provide ideal means forRead more
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The Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies and Their Application in Disease Treatment
Sep 15,2021
Study on the Pharmacological Effects of Dendrobium Nobile and its Pharmacokinetics in Rats
Dendrobium nobile has a long history of medicinal use. It is a common traditional Chinese medicine. The chemical components are divided into alkaloids, glycosides, phenanthrene and bibenzyls according to the structure type. Its pharmacological effects are mainly manifested in anti-tumor, hypoglycemic and anti- Nervous system protection and other aspects. The pharmacokinetic study of dendrobine inRead more
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Study on the Pharmacological Effects of Dendrobium Nobile and its Pharmacokinetics in Rats
Sep 14,2021
DMPK and Mechanism of Drug Interaction
When treating diseases, patients often need to receive more than one drug to enhance the therapeutic effect. When multiple drugs are administered at the same time, drug-drug interaction (DDI) may occur. Drug interaction based on pharmacokinetics is one of the main ways of drug interaction, including the interaction in the four links of drug absorption,Read more
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DMPK and Mechanism of Drug Interaction
Sep 13,2021
Study on the Pharmacokinetics of Gastrodin and its Pharmacological Effects
Gastrodia is a dry tuber of the orchid plant Gastrodia elata. It is a traditional and precious Chinese medicine for calming the liver, relieving wind and relieving spasm. Gastrodin is the main active ingredient of Gastrodia. Pharmacological studies have shown that Gastrodia has sedative, anti-convulsant, anti-epileptic properties, and increases cerebral blood flow. Protect nerve cellsRead more
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Study on the Pharmacokinetics of Gastrodin and its Pharmacological Effects
Sep 10,2021
Two Breast Cancer Endocrine Therapy Drugs have Passed the Consistency Evaluation
Breast cancer is a hormone-dependent tumor. Studies have found that for breast cancer patients who are hormone receptor-positive and cannot tolerate surgical treatment, endocrine therapy has found better results. The two commonly used breast cancer endocrine therapy drugs, tamoxifen citrate tablets and anastrozole tablets, have both passed the consistency evaluation of the quality and efficacyRead more
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Sep 10,2021
The Consistency Evaluation of Generic Drugs Requires Attention to the Particle Size of API
In the development of pharmaceutical preparations, due to the different synthesis processes of API from different sources, there may be differences in their solubility, crystal form, particle size, and impurities, which may affect the consistency of the product. In the evaluation of the consistency of generic drugs, the particle size control of API should notRead more
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The Consistency Evaluation of Generic Drugs Requires Attention to the Particle Size of API
Sep 10,2021
In Vivo and in Vitro Studies of Formulation and Consistency Evaluation of Generic Drugs
In the consistency evaluation of generic drugs, it is very important to take effective measures to accurately evaluate the in vivo and in vitro relevance of drugs. Appropriate in vivo and in vitro correlation models can accurately predict the action characteristics of the drug in vivo, thereby guiding and optimizing the formulation design, establishing moreRead more
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Sep 09,2021
Construction and Supervision of GLP Laboratory
Good Laboratory Practice(GLP) is related to drug registration. It is a regulatory document that non-clinical trials used to evaluate drug safety need to comply with. Many new drugs entered the clinic after simple animal experiments showed that they had certain effects and were not very toxic. At the same time, the clinical trial was tooRead more
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Construction and Supervision of GLP Laboratory