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Top 10 Global Clinical Research Organizations in 2021| ADC, precision and deep cultivation for targeted drug delivery| What are the three major in vitro pharmacokinetic research methods?
Aug 20,2021
What is pharmacokinetics?
In drug development, various parameters need to be established in preclinical trials before the drug is approved for preliminary testing in human subjects. Pharmacokinetics is an area of ​​research that helps scientists understand how molecules behave in the body. Overview of Pharmacokinetics Pharmacokinetics, sometimes referred to as PK (Pharmacokinetic), is a branch of pharmacology thatRead more
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What is pharmacokinetics?
Aug 20,2021
What is IND in New Drug Research?
IND Full English name: Investigational New Drug The FDA new drug review process includes two processes: IND application for new drug clinical trial application and NDA application for new drug application. IND is for clinical trial application, and NDA is for new drug marketing application. Medicilon provide the IND filing for the preclinical services. MedicilonRead more
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What is IND in New Drug Research?
Aug 19,2021
How to do a good job of biological analysis of peptide drugs?
Since Robert Bruce Merrifield synthesized the first biologically active peptide in 1953, research on peptide drugs has developed rapidly, and research on peptide drugs targeting multiple receptors has even been carried out internationally. The maturity of peptide synthesis technology has further accelerated the development of peptide drugs and has become one of the international researchRead more
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Aug 19,2021
Experimental Steps of Western Blotting Test
Western blot is a protein detection and analysis technique widely used in the fields of biology and medicine. It can be used to detect the expression level of specific proteins in tissue homogenates or cell extracts. Western blotting technology steps are mainly divided into two parts, namely SDS-polyacrylamide gel electrophoresis (SDS-PAGE) and immunoblotting. The BiologyRead more
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Experimental Steps of Western Blotting Test
Aug 18,2021
Do you know about western blotting?
IBT and LIA The Western blot detection technology currently used is not the original Western blot (IBT) but an optimized and improved method. western blotting Traditional Western Blotting (IBT): the protein is separated and purified by electrophoresis and transferred to a nitrocellulose membrane, and then autoimmune serum is used as a probe to react withRead more
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Do you know about western blotting?
Aug 18,2021
Western Blot Detection
The Biology Department of Shanghai Medicilon has extensive experience in the field of in vitro biology, through enzyme level determination, cell level determination, cell biology, biochemistry, in vitro isotope determination, stable cell line establishment, gene knockout, RNAi and MicroRNA Technology, etc., to provide a complete set of biological services. In cell biology research, sometimes itRead more
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Western Blot Detection
Aug 11,2021
Pharmaceutical Research of Innovative Drug IND Application
The development of innovative drugs is an extremely exploratory research process, which usually starts from the unknown and carries out drug screening and discovery based on unmet clinical needs. Different from generic drugs, research on innovative drugs is gradually carried out with different stages. The depth of each stage of research usually corresponds to theRead more
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Pharmaceutical Research of Innovative Drug IND Application
Aug 10,2021
Protein Purification Methods and Comparison of Advantages and Disadvantages
The separation and purification of proteins is more complicated. Proteins extracted from cells or proteins obtained from solutions containing proteins through precipitation, gradient centrifugation, salting out and other methods often contain impurities. These impurities must be removed while maintaining the biological characteristics of the protein. For the chemical activity, such as the catalytic activity ofRead more
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Protein Purification Methods and Comparison of Advantages and Disadvantages
Aug 10,2021
What are the Methods of Protein Separation and Purification?
The separation and purification of protein is an important part of biochemistry. It is a method of separating and purifying the desired target protein from the mixture using bioengineering technology. There are many protein separation companies. Medicilon is a preclinical drug development company (CRO) that can provide protein separation and purification technology services. There areRead more
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What are the Methods of Protein Separation and Purification?
Aug 10,2021
Protein Characteristics and Protein Separation Technology
Proteins generally exist as complex mixtures in tissues or cells, and each type of cell contains thousands of different proteins. The separation and purification of proteins is an arduous and arduous task. So far, there is no single or a set of ready-made methods that can extract any kind of protein from a complex mixture,Read more
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Protein Characteristics and Protein Separation Technology