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Top 10 Global Clinical Research Organizations in 2021| ADC, precision and deep cultivation for targeted drug delivery| What are the three major in vitro pharmacokinetic research methods?
Aug 10,2021
Protein Purification Methods and Comparison of Advantages and Disadvantages
The separation and purification of proteins is more complicated. Proteins extracted from cells or proteins obtained from solutions containing proteins through precipitation, gradient centrifugation, salting out and other methods often contain impurities. These impurities must be removed while maintaining the biological characteristics of the protein. For the chemical activity, such as the catalytic activity ofRead more
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Protein Purification Methods and Comparison of Advantages and Disadvantages
Aug 10,2021
What are the Methods of Protein Separation and Purification?
The separation and purification of protein is an important part of biochemistry. It is a method of separating and purifying the desired target protein from the mixture using bioengineering technology. There are many protein separation companies. Medicilon is a preclinical drug development company (CRO) that can provide protein separation and purification technology services. There areRead more
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What are the Methods of Protein Separation and Purification?
Aug 10,2021
Protein Characteristics and Protein Separation Technology
Proteins generally exist as complex mixtures in tissues or cells, and each type of cell contains thousands of different proteins. The separation and purification of proteins is an arduous and arduous task. So far, there is no single or a set of ready-made methods that can extract any kind of protein from a complex mixture,Read more
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Protein Characteristics and Protein Separation Technology
Aug 09,2021
Things about IND application
Introduction to IND IND, Investigational New Drug, generally refers to a new drug that has not been approved for marketing and is undergoing clinical trials at various stages. In actual applications, IND or CTA (clinical trial application) has become synonymous with pre-marketing human clinical trials. The IND application may be one or a sequential groupRead more
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Aug 09,2021
What is IND, NDA, ANDA?
The FDA new drug review process includes two processes: ind filing for new drug clinical trial application and new drug application NDA application. After the applicant completes the preclinical study of the new drug, he can submit an IND filing to the FDA. If the FDA does not object within 30 days of receipt ApplicantsRead more
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What is IND, NDA, ANDA?
Aug 06,2021
General Principles and Method Selection of Protein Purification
With the development of molecular biology, more and more scientific researchers have mastered various experimental techniques of molecular biology, and developed a complete set of kits to make gene cloning and expression easier and easier. However, the upstream work of molecular biology is often not the ultimate goal. The key to molecular cloning and expression
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General Principles and Method Selection of Protein Purification
Aug 05,2021
Cell and Gene Therapy: a New Direction for Innovative Therapies
Cell therapy Cell therapy is the introduction of new cells into a tissue to stimulate the body’s ability to heal itself and repair or rebuild a strong immune system in order to treat disease. Cell therapy is mainly divided into stem cell therapy and immune cell therapy. Stem cells therapy Stem cells have the abilityRead more
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Aug 04,2021
What is Bioanalysis
Biological analysis refers to the quantitative analysis of target substances in biological matrix by chromatography, chromatography-mass spectrometry, ligand binding and other techniques. Bioanalysis includes the analysis of drugs, metabolites, proteins, peptides and other large and small molecules in the matrix. In the pharmaceutical industry, bioanalysis has been widely used in the process of drug discoveryRead more
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What is Bioanalysis
Aug 04,2021
The experimental principle and operation steps of ELISA
1. Experimental principle ELISA is a highly sensitive test technique based on immunological reaction, which combines the specific reaction of antigen and antibody with the efficient catalysis of enzyme to substrate. Since the reaction of antigen and antibody is carried out in a solid phase carrier — polystyrene microtitration plate, after each addition of aRead more
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The experimental principle and operation steps of ELISA
Aug 04,2021
ELISA Experiment Guide: Indirect ELISA
Indirect ELISA Indirect ELISA is illustrated in the figure below and Figure 2. Phases I and II are similar to the direct system.Phase III involves adding unlabeled detection antibodies that are diluted in the buffer to prevent the proteins in the antiserum from nonspecifically attaching to the solid phase (the blocking buffer). It is thenRead more
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