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Top 10 Global Clinical Research Organizations in 2021| Medicilon Pharmacokinetic Services for First-in-Class Ubiquitination Inhibitor Development| ADC, precision and deep cultivation for targeted drug delivery
Aug 04,2021
What is Bioanalysis
Biological analysis refers to the quantitative analysis of target substances in biological matrix by chromatography, chromatography-mass spectrometry, ligand binding and other techniques. Bioanalysis includes the analysis of drugs, metabolites, proteins, peptides and other large and small molecules in the matrix. In the pharmaceutical industry, bioanalysis has been widely used in the process of drug discoveryRead more
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What is Bioanalysis
Aug 04,2021
The experimental principle and operation steps of ELISA
1. Experimental principle ELISA is a highly sensitive test technique based on immunological reaction, which combines the specific reaction of antigen and antibody with the efficient catalysis of enzyme to substrate. Since the reaction of antigen and antibody is carried out in a solid phase carrier — polystyrene microtitration plate, after each addition of aRead more
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The experimental principle and operation steps of ELISA
Aug 04,2021
ELISA Experiment Guide: Indirect ELISA
Indirect ELISA Indirect ELISA is illustrated in the figure below and Figure 2. Phases I and II are similar to the direct system.Phase III involves adding unlabeled detection antibodies that are diluted in the buffer to prevent the proteins in the antiserum from nonspecifically attaching to the solid phase (the blocking buffer). It is thenRead more
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Aug 03,2021
ELISA Indirect Method
As we all know, enzyme-linked immunosorbent assay (ELISA) is a technique that uses antigen-antibody interaction to quantify proteins, hormones, antibodies or viral antigens. Up to now, more than 200 research papers related to ELISA and antibody detection have been published in journals around the world every year. Among them, there are more than 70 papersRead more
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ELISA Indirect Method
Aug 03,2021
Indirect ELISA procedure
Indirect ELISA procedure-Experimental materials 1. 96-well microplate 2. TMB Experimental reagents 1. Encapsulation solution (pH9.6) : Na2CO3 0.17g, NaHCO3 0.28g, add distilled water to 100ml.4 ℃. 2. Washing solution (PBST): KH2PO4 0.2g, KCl 0.2g, NaCl 8.0g, Na2HPO4·12H2O 2.9g, Tween-20 0.5mL, add deionized water to 1000mL, adjust pH to 7.2-7.4. 3. Substrate reaction liquid: (1) SubstrateRead more
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Indirect ELISA procedure
Aug 02,2021
Drug cardiotoxicity research technique
Cardiotoxicity caused by some drugs during use is one of the life-threatening toxic side effects of patients. For example, adverse cardiac events caused by antiarrhythmic drugs have been reported from time to time. Although the incidence of such events is low, the risk is high, and the main manifestations are To prolong the QT intervalRead more
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Drug cardiotoxicity research technique
Aug 02,2021
Drug Safety Evaluation
Medicilon has a professional team and practical experience in drug safety evaluation, and can provide high-quality data and fast turnaround to support various drug safety evaluation studies. Toxicology studies can be performed in accordance with non-GLP or GLP standards. Our research platform has been rated as the Shanghai R&D public service platform. Medicilon drug safetyRead more
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Drug Safety Evaluation
Aug 02,2021
Why should GLP be implemented in new drug research?
GLP, Good Laboratory Practice, is a standard for safety evaluation experiments conducted on medicines, pesticides, food additives, cosmetics, etc., involving all aspects of laboratory work. For drug development, the implementation of GLP in pharmacology and toxicology research can guarantee the reliability, completeness and repeatability of experimental results. The top institutions in the ranking of ChineseRead more
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Why should GLP be implemented in new drug research?
Jul 31,2021
Bioanalytical Research Method
With the rapid development of the pharmaceutical industry, the research of biotechnology drugs has also entered a higher level of platform. Biotechnology drugs refer to therapeutic drugs produced through recombinant DNA technology or other innovative biotechnology-based biotechnology, which mainly include cytokines, plasminogen activators, recombinant plasma factors, growth factors, antibodies, vaccines and oligonucleotide drugs It isRead more
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Bioanalytical Research Method
Jul 31,2021
Biological analysis challenges of chemical drugs
New drug research and development is accompanied by high risks, high investment, and low returns. During this period, two important issues must be repeatedly verified: Is it safe and effective? Pharmaceutical R&D workers need to conduct systematic research on drugs through various preclinical and clinical trials to reveal or confirm the effects of test drugs,Read more
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Biological analysis challenges of chemical drugs