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Top 10 Global Clinical Research Organizations in 2021| ADC, precision and deep cultivation for targeted drug delivery| What is the subtleties of Antibody-drug conjugates
Jul 29,2021
Immunogenicity of biologic agents
Biologics have become a core component of many treatment strategies for rheumatic inflammation. Scientists often consider that immunogenicity is the important limiting factor in the early stages of development of biological agents. However, theoretical guidance is relatively limited and the determination methods for measuring immunogenicity are complex, making the development of past research difficult. ButRead more
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Immunogenicity of biologic agents
Jul 28,2021
How small molecule metabolites play important functions
Studies have shown that active metabolites can have an impact on all aspects of omics research (genomics, epigenomics, transcriptomics, and proteomics). Under this framework, metabolites mainly regulate the functions of DNA, RNA and protein through two ways, namely chemical modification and metabolite-macromolecule interactions. Chemical modification of biological macromolecules: Metabolite biological macromolecules play an important drivingRead more
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How small molecule metabolites play important functions
Jul 28,2021
Factors affecting immunogenicity
Heterogeneity: That is, the substance is different from the host's own components or the body's immune cells have never been in contact with it. The essence of the immune response is to recognize and reject the foreign body, so the antigen that stimulates the immune response generally needs to be a foreign body. Certain physicalRead more
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Jul 28,2021
Why do biological drugs have to do immunogenicity experiments?
Immunogenicity refers to the ability to stimulate the body's immune system to cause an immune response. Immunogenicity is one of the characteristics of antigens. It can act on the antigen recognition receptors of T lymphocytes and B lymphocytes to make them proliferate and differentiate, thereby producing immune effect substances, such as specific antibodies and sensitized.
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Why do biological drugs have to do immunogenicity experiments?
Jul 23,2021
What are the Contents of the New Drug Preclinical Research?
Preclinical research content of new drugs: Literature research (drug name and naming basis, title and basis) Pharmaceutical research (raw material drug technology research, preparation prescription and technology research, etc.) Pharmacology and toxicology research (general pharmacology experiment, main pharmacodynamic experiment, acute toxicity experiment, long-term toxicity experiment, etc.) The stage and purpose of the clinical research ofRead more
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What are the Contents of the New Drug Preclinical Research?
Jul 23,2021
Preclinical and Clinical Stages of Drug Development
The preclinical stage includes the discovery and optimization of lead compounds, the establishment of targets and models. Both can be used as the starting point for drug development: 1. Lead compounds are obtained through screening models, the lead compounds are optimized, and then the model is used for evaluation; 2. Medicinal chemistry can also beRead more
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Preclinical and Clinical Stages of Drug Development
Jul 23,2021
Pharmaceutical Stability Test
The stability of a drug substance or preparation refers to its ability to maintain physical, chemical, biological and microbiological properties. Stability research is based on the systematic research and understanding of APIs or preparations and their production processes. The quality characteristics of APIs or preparations obtained through design tests will vary under the influence ofRead more
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Pharmaceutical Stability Test
Jul 22,2021
Medicilon appoints Dr. Xuedong Dai as Executive Vice President of International Discovery Service Unit
Recently, Shanghai Medicilon Inc. (stock code: 688202.SH) (Medicilon) announced the appointment of Dr. Xuedong Dai as Executive Vice President of International Discovery Service Unit. Dr. Xuedong Dai Executive Vice President of International Discovery Service Unit Dr. Xuedong Dai, Ph.D. in Organic Chemistry and Postdoctoral at MIT, has been deeply involved in the research and developmentRead more
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Medicilon appoints Dr. Xuedong Dai as Executive Vice President of International Discovery Service Unit
Jul 22,2021
What is Accelerated Stability Testing?
The accelerated stability test places perishable products under stress to estimate the shelf life under normal conditions. In this test, the company encourages the product to fail in a short period of time in harsh environments, and use this to estimate what might happen under normal conditions. This eliminates the need to store the productRead more
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What is Accelerated Stability Testing?
Jul 22,2021
New star in protein targeted degradation technology-LYTAC
Targeted protein degradation technology (Proteolysis TArgeting Chimeras, PROTAC) is an emerging hot drug development area following small molecule inhibitors (SMI) and monoclonal antibody (mAb) drugs. Compared with the latter two, PROTAC has unique advantages, being able to target numerous protein molecules that were previously considered "undruggable”. Hundreds of PROTAC molecules have been or are beingRead more
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New star in protein targeted degradation technology-LYTAC