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Top 10 Global Clinical Research Organizations in 2021| Medicilon Pharmacokinetic Services for First-in-Class Ubiquitination Inhibitor Development| ADC, precision and deep cultivation for targeted drug delivery
Jul 31,2021
Discovery of hit compounds
The discovery of hit compounds determines the starting point of the entire drug discovery process and is of vital importance. The confirmation stage of the hit compound is as follows: Exclude compounds with potential reactivity, interference with testing, or self-aggregation. Repeated activity test: For the selected target, the active compound obtained by high-throughput screening isRead more
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Jul 30,2021
Pre-formulation Research of Generic Drugs
The purpose and importance of pre-prescription research The purpose of the Pre-formulation research is to provide the basis for the prescription process design, and to provide a clear mechanism of targeted solutions to the problems in the prescription process research. The quality characteristics of the final product are largely determined by the nature of theRead more
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Pre-formulation Research of Generic Drugs
Jul 30,2021
Preformulation Research for New Drug Development
Generally speaking, the several necessary stages of new drug development are: 1) pre-formulation research; 2) dosage form selection, which is to determine the appropriate dosage form according to the physical and chemical properties of the drug, clinical treatment and application needs; 3) prescription research, That is, according to the physical and chemical properties of theRead more
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Preformulation Research for New Drug Development
Jul 30,2021
The Value and Importance of Preformulation Research
The purpose of preformulation research is to provide a basis for preformulation process design, and to provide clear mechanism and targeted solutions to problems arising in the research of preformulation process. The quality characteristics of the final product are largely determined by the properties of the drug substance. Although there are many ways to optimizeRead more
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The Value and Importance of Preformulation Research
Jul 30,2021
Preformulation Research
Medicilon has been offering high quality analytical testing services to the pharmaceutical industry for decades. We offer a wide range of quality control testing services to support drug research, registration and production. Biopharmaceutical companies also use many of the same services and Medicilon has also added new services to accommodate their unique needs (detailed inRead more
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Preformulation Research
Jul 29,2021
Metabolites Modify Proteins
Metabolism is the most basic characteristic of life activities. On the one hand, metabolism can directly meet the material needs of individual growth and development through the synthesis of energy and biomacromolecules. On the other hand, more and more studies have shown that metabolites accumulated during metabolism, such as lactic acid, succinic acid, coenzyme A,Read more
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Metabolites Modify Proteins
Jul 29,2021
Immunogenicity of biologic agents
Biologics have become a core component of many treatment strategies for rheumatic inflammation. Scientists often consider that immunogenicity is the important limiting factor in the early stages of development of biological agents. However, theoretical guidance is relatively limited and the determination methods for measuring immunogenicity are complex, making the development of past research difficult. ButRead more
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Immunogenicity of biologic agents
Jul 28,2021
How small molecule metabolites play important functions
Studies have shown that active metabolites can have an impact on all aspects of omics research (genomics, epigenomics, transcriptomics, and proteomics). Under this framework, metabolites mainly regulate the functions of DNA, RNA and protein through two ways, namely chemical modification and metabolite-macromolecule interactions. Chemical modification of biological macromolecules: Metabolite biological macromolecules play an important drivingRead more
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How small molecule metabolites play important functions
Jul 28,2021
Factors affecting immunogenicity
Heterogeneity: That is, the substance is different from the host's own components or the body's immune cells have never been in contact with it. The essence of the immune response is to recognize and reject the foreign body, so the antigen that stimulates the immune response generally needs to be a foreign body. Certain physicalRead more
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Jul 28,2021
Why do biological drugs have to do immunogenicity experiments?
Immunogenicity refers to the ability to stimulate the body's immune system to cause an immune response. Immunogenicity is one of the characteristics of antigens. It can act on the antigen recognition receptors of T lymphocytes and B lymphocytes to make them proliferate and differentiate, thereby producing immune effect substances, such as specific antibodies and sensitized.
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Why do biological drugs have to do immunogenicity experiments?