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Top 10 Global Clinical Research Organizations in 2021| ADC, precision and deep cultivation for targeted drug delivery| What are the three major in vitro pharmacokinetic research methods?
Jul 21,2021
The Second Generation LYTAC Technology
Targeted protein degradation is a very promising treatment, and it is also an important tool for discovering cell biology pathways and apoptosis mechanisms. Many methods for targeted protein degradation have been established, such as targeted induced protein degradation technology (PROTAC), autophagy targeted chimera (AUTAC), etc., but most of these methods target proteins in the cytoplasm.Read more
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Jul 21,2021
PROTAC and LYTAC
Most drugs block or modulate the function of the target protein by binding to a specific site of the target protein. However, the activity of many proteins cannot be changed in this way. Protein degradation agents represented by Proteolis-Targeting Chimaeras (PROTACs) can change the function of proteins in an unconventional way. This new type ofRead more
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Jul 13,2021
Ligand Binding Analysis of Drug Screening Methods
The acquisition of lead compounds and the production of drugs are important links in the process of drug screening. Drug screening involves a series of steps to select the most suitable chemical entity for drug development to clinical application, including pharmacological research and toxicological research. Research to determine the safety and effectiveness of the drug.Read more
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Ligand Binding Analysis of Drug Screening Methods
Jul 13,2021
Caenorhabditis elegans, a model animal for studying the regulation of serotonin in the brain
With the continuous improvement of biological science and technology, the current models constructed using model organisms are playing an increasingly important role in drug screening. Patients with depression and anxiety often have lower levels of serotonin in their bodies. For these patients, some drugs that increase serotonin levels are often used clinically. Serotonin, also knownRead more
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Caenorhabditis elegans, a model animal for studying the regulation of serotonin in the brain
Jul 13,2021
Scientists have discovered a new anti-cancer drug-EBV protein inhibitor
Epstein-Barr virus (EBV) is a herpes virus that is pathogenic to humans. It has been found to be associated with nasopharyngeal cancer, some gastric cancer, laryngeal cancer and Hodgkin's lymphoma. Although the proportion of EB virus directly causing cancer is very low, because of the high proportion of human infections, the eradication of cancer causedRead more
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Jul 13,2021
Aloe-emodin inhibits tumor cell activity
Anthraquinone compounds are one of the important active components of aloe, which mainly include aloe emodin, chrysophanol, emodin, rhein acid and emodin methyl ether. A large number of cell experiments have shown that the anthraquinone compound aloe emodin can inhibit tumor cell proliferation and induce tumor cell apoptosis by blocking cell cycle. Therefore, the researchRead more
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Aloe-emodin inhibits tumor cell activity
Jul 13,2021
The role of in vitro MTT experiment in preclinical efficacy evaluation of anticancer drugs
Practical methods for evaluating tumor cell growth and survival are very important in tumor research.In preclinical efficacy evaluation of antitumor drugs, in vitro MTT pharmacodynamics experiments are often used to explore the inhibitory effect of compounds on the growth of tumor cells in vitro, or in vivo tumor transplantation pharmacodynamics experiments are used to exploreRead more
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The role of in vitro MTT experiment in preclinical efficacy evaluation of anticancer drugs
Jul 12,2021
Effect of chemokine ligand 2 on the learning and memory ability of rats
CC chemokine 2 (CCL2), which is generally expressed in white blood cells and rarely expressed in normal nerve tissues, plays an important role in the innate immunity caused by tissue damage and some diseases. Numerous studies have found that CCL2 can damage the learning and memory of rats. In order to study the effect andRead more
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Effect of chemokine ligand 2 on the learning and memory ability of rats
Jul 07,2021
Selection Principles of Laboratory Animals for Drug Preclinical Research
In the process of new drug development, candidate drugs must undergo a comprehensive assessment of their acute, chronic, developmental and reproductive toxicity and carcinogenicity before entering the clinical trial stage to ensure the effectiveness and safety of the drug after it is administered to the human body. Because laboratory animals usually have similar molecular targetsRead more
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Selection Principles of Laboratory Animals for Drug Preclinical Research
Jul 07,2021
Pre-clinical Trial Program of Stem Cell Preparations
In recent years, the research of stem cell-based cell therapy has developed rapidly at home and abroad.In particular, a number of clinical trials have been initiated in the fields of degenerative diseases, cirrhosis of the liver, diseases of the immune system and graft-versus-host diseases.The clinical application of stem cells is developing rapidly, and the numberRead more
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