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Top 10 Global Clinical Research Organizations in 2021| ADC, precision and deep cultivation for targeted drug delivery| What are the three major in vitro pharmacokinetic research methods?
Jun 30,2021
Commonly used detector for HPLC
The role of the liquid chromatography detector is to convert the changes in the composition and content of the sample in the column effluent into detectable signals. Commonly used detectors include ultraviolet absorption, fluorescence, refractive index, and chemiluminescence. 1 UV absorption detector Ultraviolet absorption (UV) detector is currently the most widely used detector for HPLC.Read more
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Jun 29,2021
2019 Domestic Class 1 New Drug IND Ranking
In 2019, the development of innovative drugs is still hot, and the number of domestic Class 1 new drug INDs continues to exceed 110, reaching a new high; 8 INDs of Chia Tai Tianqing were accepted by the national CDE, ranking first among all domestic pharmaceutical companies, followed by stone Pharmaceutical Group, Guangdong Dongyang Sunshine,Read more
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Jun 29,2021
The Meaning of IND, NDA and ANDA
IND IND is the abbreviation of Investigational New Drug, which refers to the approval of clinical research of new drugs. The production of new drugs requires two administrative approvals, one is in the clinical research phase (IND application), and the other is the completion of the clinical research registration (NDA application). Medicilon is the firstRead more
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The Meaning of IND, NDA and ANDA
Jun 25,2021
Medicilon's
When AI accurately predicts the "difficult” protein 3D structure; When AI completes the new drug design within 21 days; When AI discovers a new mechanism of idiopathic pulmonary fibrosis drugs.  Cutting-edge technology is driving the innovation revolution.  With the empowerment of AI, how will the future of "smart” medicine evolve? On June 18, the 12thRead more
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Medicilon's
Jun 23,2021
How to do pre-clinical research on chemical drugs and biological drugs? (2)
Biological medicine refers to a class of medicines used for prevention, treatment and diagnosis that are manufactured using biological, biological tissue, cells, body fluids, etc., using the research results of biology, medicine, and biochemistry. Biological drugs, especially antibody drugs, have the advantages of high targeting and good selectivity, so the curative effect is accurate andRead more
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How to do pre-clinical research on chemical drugs and biological drugs? (2)
Jun 23,2021
How to do pre-clinical research on chemical drugs and biological drugs? (1)
In recent decades, with the continuous emergence of drug targets and the continuous innovation of drug screening and optimization technologies, the global small molecule and macromolecular drug market has maintained stable and rapid growth. At the same time, the continuous increase in the cost of new drug research and development has gradually become the normRead more
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How to do pre-clinical research on chemical drugs and biological drugs? (1)
Jun 03,2021
Medicilon PROTAC Drug Discovery Research Platform
PROTAC technology has a unique mechanism The PROTAC molecule specifically recognizes and binds to the target protein through the target protein ligand (POI Ligand) at one end and the E3 Ligase through the E3 Ubiquitin Ligase Ligand (E3 Ligase Ligand) at the other end.Forming the POI-PROTAC-E3 Ligase Ternary ComplexIn this ternary complex, the target proteinRead more
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Medicilon PROTAC Drug Discovery Research Platform
May 07,2021
Analysis of Three Factors Influencing Ames Test
Salmonella reverse mutation test. The Ames test is currently the internationally recognized test of choice for detecting the mutagenicity and carcinogenicity of new drugs. This test uses the nature of the histidine auxotrophic mutant (His-) of Salmonella typhimurium to produce revertives. Preliminary screening of the mutagenicity of chemical substances. The study found that the concentrationRead more
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Analysis of Three Factors Influencing Ames Test
May 07,2021
What are the main research contents of the local toxicity test?
The test designed to study the toxicity caused by topical medication is a local toxicity test, which is an important part of toxicology research, including irritation test, allergic test, hemolysis and skin toxicity test. Generally speaking, ointments, drops, lotions, scalp patches, sprays, powders for external use and other dosage forms must be tested for localRead more
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What are the main research contents of the local toxicity test?
May 07,2021
A brief description of the SEND standard
For pharmaceutical R&D personnel, the amount of data in pharmaceutical research is very large. Integrating such a large amount of data is a very complicated task. Compared with traditional paper declaration, electronic drug declaration has many obvious advantages. For example, the SEND format can integrate data into a SEND data set, and visual tools canRead more
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A brief description of the SEND standard