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Top 10 Global Clinical Research Organizations in 2021| Medicilon Pharmacokinetic Services for First-in-Class Ubiquitination Inhibitor Development| ADC, precision and deep cultivation for targeted drug delivery
Jul 13,2021
Scientists have discovered a new anti-cancer drug-EBV protein inhibitor
Epstein-Barr virus (EBV) is a herpes virus that is pathogenic to humans. It has been found to be associated with nasopharyngeal cancer, some gastric cancer, laryngeal cancer and Hodgkin's lymphoma. Although the proportion of EB virus directly causing cancer is very low, because of the high proportion of human infections, the eradication of cancer causedRead more
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Jul 13,2021
Aloe-emodin inhibits tumor cell activity
Anthraquinone compounds are one of the important active components of aloe, which mainly include aloe emodin, chrysophanol, emodin, rhein acid and emodin methyl ether. A large number of cell experiments have shown that the anthraquinone compound aloe emodin can inhibit tumor cell proliferation and induce tumor cell apoptosis by blocking cell cycle. Therefore, the researchRead more
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Aloe-emodin inhibits tumor cell activity
Jul 13,2021
The role of in vitro MTT experiment in preclinical efficacy evaluation of anticancer drugs
Practical methods for evaluating tumor cell growth and survival are very important in tumor research.In preclinical efficacy evaluation of antitumor drugs, in vitro MTT pharmacodynamics experiments are often used to explore the inhibitory effect of compounds on the growth of tumor cells in vitro, or in vivo tumor transplantation pharmacodynamics experiments are used to exploreRead more
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The role of in vitro MTT experiment in preclinical efficacy evaluation of anticancer drugs
Jul 12,2021
Effect of chemokine ligand 2 on the learning and memory ability of rats
CC chemokine 2 (CCL2), which is generally expressed in white blood cells and rarely expressed in normal nerve tissues, plays an important role in the innate immunity caused by tissue damage and some diseases. Numerous studies have found that CCL2 can damage the learning and memory of rats. In order to study the effect andRead more
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Effect of chemokine ligand 2 on the learning and memory ability of rats
Jul 07,2021
Selection Principles of Laboratory Animals for Drug Preclinical Research
In the process of new drug development, candidate drugs must undergo a comprehensive assessment of their acute, chronic, developmental and reproductive toxicity and carcinogenicity before entering the clinical trial stage to ensure the effectiveness and safety of the drug after it is administered to the human body. Because laboratory animals usually have similar molecular targetsRead more
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Selection Principles of Laboratory Animals for Drug Preclinical Research
Jul 07,2021
Pre-clinical Trial Program of Stem Cell Preparations
In recent years, the research of stem cell-based cell therapy has developed rapidly at home and abroad.In particular, a number of clinical trials have been initiated in the fields of degenerative diseases, cirrhosis of the liver, diseases of the immune system and graft-versus-host diseases.The clinical application of stem cells is developing rapidly, and the numberRead more
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Jun 30,2021
Commonly used detector for HPLC
The role of the liquid chromatography detector is to convert the changes in the composition and content of the sample in the column effluent into detectable signals. Commonly used detectors include ultraviolet absorption, fluorescence, refractive index, and chemiluminescence. 1 UV absorption detector Ultraviolet absorption (UV) detector is currently the most widely used detector for HPLC.Read more
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Jun 29,2021
2019 Domestic Class 1 New Drug IND Ranking
In 2019, the development of innovative drugs is still hot, and the number of domestic Class 1 new drug INDs continues to exceed 110, reaching a new high; 8 INDs of Chia Tai Tianqing were accepted by the national CDE, ranking first among all domestic pharmaceutical companies, followed by stone Pharmaceutical Group, Guangdong Dongyang Sunshine,Read more
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Jun 29,2021
The Meaning of IND, NDA and ANDA
IND IND is the abbreviation of Investigational New Drug, which refers to the approval of clinical research of new drugs. The production of new drugs requires two administrative approvals, one is in the clinical research phase (IND application), and the other is the completion of the clinical research registration (NDA application). Medicilon is the firstRead more
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The Meaning of IND, NDA and ANDA
Jun 23,2021
How to do pre-clinical research on chemical drugs and biological drugs? (2)
Biological medicine refers to a class of medicines used for prevention, treatment and diagnosis that are manufactured using biological, biological tissue, cells, body fluids, etc., using the research results of biology, medicine, and biochemistry. Biological drugs, especially antibody drugs, have the advantages of high targeting and good selectivity, so the curative effect is accurate andRead more
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How to do pre-clinical research on chemical drugs and biological drugs? (2)