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Top 10 Global Clinical Research Organizations in 2021| ADC, precision and deep cultivation for targeted drug delivery| What are the three major in vitro pharmacokinetic research methods?
May 07,2021
Analysis of Three Factors Influencing Ames Test
Salmonella reverse mutation test. The Ames test is currently the internationally recognized test of choice for detecting the mutagenicity and carcinogenicity of new drugs. This test uses the nature of the histidine auxotrophic mutant (His-) of Salmonella typhimurium to produce revertives. Preliminary screening of the mutagenicity of chemical substances. The study found that the concentrationRead more
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Analysis of Three Factors Influencing Ames Test
May 07,2021
What are the main research contents of the local toxicity test?
The test designed to study the toxicity caused by topical medication is a local toxicity test, which is an important part of toxicology research, including irritation test, allergic test, hemolysis and skin toxicity test. Generally speaking, ointments, drops, lotions, scalp patches, sprays, powders for external use and other dosage forms must be tested for localRead more
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What are the main research contents of the local toxicity test?
May 07,2021
A brief description of the SEND standard
For pharmaceutical R&D personnel, the amount of data in pharmaceutical research is very large. Integrating such a large amount of data is a very complicated task. Compared with traditional paper declaration, electronic drug declaration has many obvious advantages. For example, the SEND format can integrate data into a SEND data set, and visual tools canRead more
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A brief description of the SEND standard
May 07,2021
Targeting the membrane positioning of aquaporin 4 is expected to treat central nervous system edema
Targeted aquaporin 4 (AQP4) is abundantly distributed in the central nervous system, and is involved in the reabsorption of cerebrospinal fluid, osmotic pressure regulation, etc., and is related to the occurrence of cerebral edema and spinal cord edema. Recently, it was published in the latest issue of the scientific journal Cell that targeting aquaporin-4 subcellularRead more
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May 06,2021
Analysis of the influence of compound dosage on pharmacological effects
In new drug research, determining the dosage of different animals is a problem that needs to be paid attention to in pharmacological research. The pharmacological effect is proportional to the dose of the drug within a certain range, that is, the dose-effect relationship. The dose of the drug has an impact on the effect ofRead more
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Apr 30,2021
What are the commonly used cell lines for insect cell baculovirus vector expression systems
Insect cell baculovirus vector expression system is widely used in the production of recombinant proteins. Compared with typical E. coli and yeast expression systems, it has a powerful polyhedrin promoter, so it has high expression performance and can perform correctly. The post-translational modification to produce functional and immunogenetic active recombinant protein. Moreover, the virus andRead more
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What are the commonly used cell lines for insect cell baculovirus vector expression systems
Apr 30,2021
Study on the Expression and Purification of Caveolin-1 Protein and Its Relationship with Tumor
Caveolin exists in a variety of terminally differentiated cells such as fibroblasts, endothelial cells, and type I alveolar epithelium. It is a flask-shaped micro-recessed structure with a diameter of 50-100 nm on the cytoplasmic membrane. Caveolin-1 protein is the cellar Important structural protein. Studies have suggested that Caveolin-1 participates in the regulation of the activityRead more
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Study on the Expression and Purification of Caveolin-1 Protein and Its Relationship with Tumor
Apr 29,2021
Analysis of Two Common Types of Baculovirus Expression Vectors
Baculovirus is a larger type of insect virus. It can not only be used as an important biological insecticide, but also can be used in baculovirus vector expression system. It has excellent performance in agriculture, basic molecular biology and medicine. Its important role.
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Analysis of Two Common Types of Baculovirus Expression Vectors
Apr 29,2021
The effect of target gene copy number on the efficiency of expressing foreign protein in yeast system
Yeast is a single-celled lower eukaryote with ordinary culture conditions, rapid growth and reproduction, and can tolerate high hydrostatic pressure. It can be mass-produced when used to express genetic engineering products, effectively reducing production costs. The vector of the yeast expression system is generally a shuttle plasmid, which belongs to the E. coli-yeast shuttle vector,Read more
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The effect of target gene copy number on the efficiency of expressing foreign protein in yeast system
Apr 29,2021
Research on using insect cell expression system to express immune-related molecules
Both CD4 molecule and IL-12 are hot molecules in tumor immunotherapy research. Among them, CD4 molecule has important immunological functions, it can participate in the body's immune response, and the cytokines of the IL-12 family of interleukins play a role in immune regulation. The immune response can be formed by directly inducing the development ofRead more
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Research on using insect cell expression system to express immune-related molecules