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Top 10 Global CDMO Enterprises| The Meaning of IND, NDA and ANDA| Top 10 Global Clinical Research Organizations in 2021
Nov 12,2015
Cell Compacts Its DNA when Starved of Oxygen or Nutrients
    For cells to function normally, large parts of their DNA structure have to be open and accessible so molecules that read genetic code can produce instructions for making proteins. Now, researchers have discovered that when cells are starved of oxygen or nutrients, they compact their DNA, making it difficult for these normal functions to continue.Read more
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Nov 11,2015
Lowering Enzyme Activity Turns Up Volume for Deafness
Mitochondrial diseases represent a collection of genetic disorders whose symptoms vary widely from muscle weakness and cardiac defects to blindness and dementia. In one particular disorder, a mitochondrial DNA (mtDNA) mutation is responsible for a type of human hereditary deafness that worsens over time and can lead to a profound hearing loss. Now, a teamRead more
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Lowering Enzyme Activity Turns Up Volume for Deafness
Nov 10,2015
Researchers Zero In on Cellular Stress Link to Heart Disorders
Scientists at Duke Medicine have identified a novel molecular pathway involved in heart attacks and death from heart disease. The researchers, who published a study, "Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis,” in PLOS Genetics, found that stress on the endoplasmic reticulum (ER) is associated with riskRead more
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Researchers Zero In on Cellular Stress Link to Heart Disorders
Nov 10,2015
New Animal Facility of Medicilon Passed Shanghai Animal Committee Audit
The newly built vivarium by Medicilon has passed the audition of Shanghai Animal Committee.  Combined with the original vivarium, the vivarium capacity of Medicilon is doubled up.  This means that Medicilon could provide and handle more and different experiments and projects.   Medicilon is always keen to improve our team and quality service to meetRead more
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Nov 10,2015
Moving Closer to Solving the MRSA Vaccine Puzzle
    Immunologists from Trinity College in Dublin say they have unearthed a key piece of the MRSA vaccine puzzle by identifying specific T-helper cells whose role in the immune response is critical in affecting infection outcomes. The researchers were able to develop a model vaccine, which targeted T-helper type 1 cells, and then showed experimentally thatRead more
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Nov 09,2015
Artificial DNA Base Pair Used as Amplifiable Marker of Genomic Damage
The genome sustains so much wear and tear, much of it hardly noticeable, that even the small portion of DNA damage that stays unrepaired far exceeds our inventory-taking abilities. Taking stock of DNA damage, however, may become a lot easier now that scientists at the University of Utah have developed a new method that canRead more
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Nov 09,2015
Neonatal-to-Adult Liver Maturation Depends on Alternative Splicing
    When a baby is born, many of its tissues are still only partly formed. They need to be further developed before they are capable of performing adult functions. In general, neonatal-to-adult tissue remodeling is poorly understood, but at least one particularly challenging type of remodeling has yielded some of its secrets. The tissue of interestRead more
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Nov 09,2015
RNAi Technique Used to Help Skin Injuries Heal Quicker
    Researchers at Louisiana State University along with collaborators at Northwestern University say they have discovered a new way to prevent inflammation and to accelerate the skin’s healing process. After five years of research, they identified the gene regulation pathway, which involves the body’s sodium sensor called Nax (scn7a) that triggers inflammation. They found aRead more
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Nov 06,2015
Stem Cell, Tissue Cell Confabs Sustain Blood Renewal
    From the depths of the hematopoietic niche, blood cells emerge to sustain life. But what sustains the flow of blood cells, or accounts for the occasional surge? The shallow answer is, of course, blood stem cells. A deeper inquiry, however, might consider how blood stem cells are able to rise to a wide range ofRead more
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Nov 06,2015
Personalized Medicine Starts Predicting Personalized Side Effects
Personalized medicine is usually about personalized benefits. For example, a drug's potential to benefit a particular patient can be determined on the basis of that patient's unique genetic make-up, as indicated, for example, by a genomic or metabolomic profile. But what about a drug's capacity for side effects? If personalized medicine can predict, on aRead more
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