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Top 10 Global CDMO Enterprises| Top 10 Global Clinical Research Organizations in 2021| The Meaning of IND, NDA and ANDA
Nov 05,2015
Decades Old DNA Replication Models Called into Question
    It may be time to update biology texts to reflect newly published data from a collaborative team of scientists at Rockefeller University, Stony Brook University, and the U.S. Department of Energy's Brookhaven National Laboratory. Using cutting-edge electron microscopy (EM) techniques, the investigators gathered the first ever images of the fully assembled replisome, providing new insightRead more
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Nov 05,2015
Junk DNA Kept in Good Repair by Nuclear Membrane
Heterochromatin has the dubious distinction of being called the "dark matter” of DNA, and it has even suffered the indignity of being dismissed as "junk DNA.” But it seems to get more respectful treatment inside the nucleus, where it has the benefit of a special repair mechanism. This mechanism, discovered by scientists based at theRead more
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Nov 04,2015
Gene Found that Regulates Stem Cell Number Production
    A scientific team from the University of Southern California (USC) and the University of California, San Diego have described an important gene that maintains a critical balance between producing too many and too few stem cells. Called Prkci, the gene influences whether stem cells self-renew to produce more stem cells, or differentiate into more specializedRead more
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Nov 04,2015
Tumor RNA in Platelets May Diagnose and Classify Cancer
    The age of fast, accurate, and noninvasive cancer screening is rapidly becoming reality.  Analysis of tumor RNA carried in platelets — blood components best known for their role in clotting — may prove to be more useful than other “liquid biopsy” technologies for diagnosing cancer and determining its primary location and potential therapeutic approaches.  TheRead more
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Nov 03,2015
Insights Gained on Diseases Linked to Protein Aggregation
    Scientists at Dartmouth say they have found that some proteins turn into liquid droplets on the way to becoming toxic solids implicated in neurodegenerative diseases and other genetic disorders.     The team studied proteins that have a massive expansion of a single amino acid, glutamine, typically associated with toxic protein solids. For example, neurodegenerative-linked proteins suchRead more
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Nov 03,2015
Are Embryonic Stem Cells and Artificial Stem Cells Equivalent?
    Harvard Stem Cell Institute (HSCI) researchers at Massachusetts General Hospital and Harvard Medical Shcool have found new evidence suggesting some human induced pluripotent stem cells are the "functional equivalent” of human embryonic stem cells, a finding that may begin to settle a long running argument.     Comparing embryonic stem cells and induced pluripotent stem cells canRead more
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Are Embryonic Stem Cells and Artificial Stem Cells Equivalent?
Nov 02,2015
New and Unusual DNA Repair Activity Identified
    Hot on the heels of the recent announcement of the Nobel Prize in Chemistry being awarded for seminal discoveries in the area of DNA repair, researchers at Vanderbilt University have published data describing new enzymatic activity for a DNA glycosylase discovered previously in the bacteria Bacillus cereus.       When Watson and Crick first published theirRead more
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Nov 02,2015
Exosome Scouts Help Tumors Populate Distant Organs
    When certain types of cancer spread, they seem to prefer particular organs in the body, a choosiness that led Stephen Paget to propose the "seed and soil” hypothesis. This hypothesis, now more than 100 years old, suggests that different organs are somehow more receptive to certain types of cancer, just as different soils seem toRead more
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Exosome Scouts Help Tumors Populate Distant Organs
Oct 30,2015
Using CRISPR as a High-Throughput Cancer Screening and Modeling Tool
    A contingent of researchers from the UK, Germany, and Spain have recently developed a novel CRISPR/Cas9 system that they believe can be utilized as a multiplexed screening approach to study and model cancer development in mice. In the current study, the investigators directly mutated genes within adult mouse livers to elucidate their role in cancerRead more
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Using CRISPR as a High-Throughput Cancer Screening and Modeling Tool
Oct 30,2015
Simple Solution Improves Flu Vaccine
For decades, immunologists have been on a frenetic quest to find the holy-grail for influenza vaccines—a cross-protective mixture that would allow the immune system to react to a variety of flu strains after a single inoculation. Now, researchers at the University of Melbourne may have found a fairly simple workaround that boosts the effectiveness andRead more
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