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Top 10 Global CDMO Enterprises| Top 10 Global Clinical Research Organizations in 2021| The Meaning of IND, NDA and ANDA
Oct 23,2015
X-Chromosome Silencing Depends on Antisense RNA
    Think of the silencing of the X chromosome as a construction project. Then, imagine you hear the beeping of heavy machinery operating in reverse. That's the sound of the Xist gene being transcribed in the backwards, or antisense, direction. The Xist gene is read in the forward direction too, otherwise it wouldn't generate a long,Read more
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Oct 23,2015
Progress of PCSK9 inhibitors displays power of human genetics in finding future therapies
An update on PCSK9 inhibitors presented at the annual Cardiometabolic Health Congress showcased the rapid development of the agents, from gene to antibody, and examined where the field is moving in applying the therapies. "This has been a remarkably short period from discovery to actually having a therapeutic,” Jay Horton, MD, chief of the divisionRead more
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Oct 22,2015
Hi-Res Structure of Aging and Cancer Enzyme Comes into View
    Years after Elizabeth Blackburn, Ph.D. won the Nobel Prize for her seminal work on the molecular nature of telomeres and co-discovery of the ribonucleoprotein enzyme telomerase, scientists still struggle with fully understanding the intricacies surrounding this inherent genetic mechanism for maintaining genomic stability.  The telomerase enzyme is known to play a significant role in agingRead more
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Oct 22,2015
CRISPR-Fine Screen of Human Genome Identifies Essential Genes
For the first time, a comprehensive set of cell-essential genes in the human genome has been compiled. This feat, which not only points to deeper studies of human genetics but also suggests a strategy for finding vulnerabilities in cancer cells, was achieved thanks to the CRISPR-Cas9 gene-editing system. This system proved sufficiently rigorous to succeedRead more
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Oct 21,2015
Protein Found in Malaria Could Help Stop Cancer
    The devastating global effects of malaria have been widely documented, but the presentation of the disease during pregnancy is particular troubling and confounding to researchers. Women living in endemic areas face a much greater risk of contracting malaria when they are pregnant, and associated complications once infected with the parasite. While an average adult residingRead more
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Protein Found in Malaria Could Help Stop Cancer
Oct 21,2015
FDA Places Advaxis Cancer Immunotherapy on Clinical Hold
    Advaxis announced that the FDA has placed a clinical hold on its experimental immunotherapy axalimogene filolisbac, after the agency received a safety report on the death of a patient treated with the cervical cancer immunotherapy in a clinical study two years ago.  The company noted that the clinical hold will affect four clinical trials ofRead more
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Oct 20,2015
New Protein Cleanup Factors Found to Control Bacterial Growth
    Biochemists have long known that crucial cell processes depend on a highly regulated cleanup system known as proteolysis, where specialized proteins called proteases degrade damaged or no-longer-needed proteins. They must destroy specific targets without damaging other proteins, but how this orderly destruction works is unknown in many cases. Now researchers report finding how an essentialRead more
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Oct 20,2015
Editing of Pig DNA May Lead to More Organs for Human
Before pig organs can be made safe for transplantation into human patients, two problems need to be solved. Both problems, ultimately, come down to features of the pig genome. First, the pig genome contains genes that give rise to proteins that the human immune system will not tolerate. Second, it contains retroviruses that could beRead more
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Oct 19,2015
Immune Gene Prevents Parkinson's Disease
    An estimated seven to ten million people worldwide are living with Parkinson's disease (PD), which is an incurable and progressive disease of the nervous system affecting movement and cognitive function. More than half of PD patients develop progressive disease showing signs of dementia similar to Alzheimer's disease. A research team at University of Copenhagen, Denmark,Read more
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Immune Gene Prevents Parkinson's Disease
Oct 19,2015
Antioxidant Use May Promote Spread of Cancer
    A team of scientists at the Children's Research Institute at UT Southwestern (CRI) has made a discovery that suggests cancer cells benefit more from antioxidants than normal cells, raising concerns about the use of dietary antioxidants by patients with cancer. The studies were conducted in specialized mice that had been transplanted with melanoma cells fromRead more
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