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Top 10 Global CDMO Enterprises| Top 10 Global Clinical Research Organizations in 2021| The Meaning of IND, NDA and ANDA
Sep 15,2015
cGMP Trigger for Cell Signaling By Optogenetic Fungal Protein
Cyclic GMP (cGMP) signaling regulates multiple biological functions through activation of protein kinase G and cyclic nucleotide-gated (CNG) channels. In sensory neurons, cGMP permits signal modulation, amplification and encoding, before depolarization. The optogenetic toolbox keeps expanding. Besides containing light-sensitive proteins that can be used to adjust membrane potential, protein-protein interactions, and gene expression, the optogeneticRead more
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Sep 15,2015
Broadly Neutralizing Antibody Can Pin HIV with Either of Dual Holds
    An antibody is a large, Y-shape protein produced by plasma cells that is used by the immune system to identify and neutralize pathogens such as bacteria and viruses.   Even broadly neutralizing antibodies (bNAbs) have difficulty grappling with HIV, but one such antibody has shown that it can prevent HIV from slipping away. This particular bNAb,Read more
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Broadly Neutralizing Antibody Can Pin HIV with Either of Dual Holds
Sep 14,2015
Researchers Decipher Mechanism Linking Periodontitis and Heart Disease
Scientists say they have shown that a periodontal pathogen causes changes in gene expression that boost inflammation and atherosclerosis in aortic smooth muscle cells, thus raising the risk of a heart attack. The research ("Gingipains from the periodontal pathogen Porphyromonas gingivalis play a significant role in regulation of Angiopoietin 1 and Angiopoietin 2 in humanRead more
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Researchers Decipher Mechanism Linking Periodontitis and Heart Disease
Sep 14,2015
Dengue Hemorrhagic Shock Protein Identified, Shows Potential as Vaccine
    Dengue fever, also known as breakbone fever, is a mosquito-borne tropical disease caused by the dengue virus.  If you've made it to the end of the summer with no mosquito bites, consider yourself lucky. There are many places in the world where these vexatious insects carry debilitating diseases that can not only adversely affect individuals,Read more
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Sep 14,2015
Last week brought the first U.S. launch in a new category called “biosimilars.”
Years after discounted versions of some of the most expensive drugs ever went on sale in other countries, they’re finally coming to the world’s biggest medicine market. Last week brought the first U.S. launch in a new category called “biosimilars.” They’re near-copies of powerful prescription drugs known as biologics “manufactured” in living cells. Biologics areRead more
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Sep 11,2015
Possible Evidence for Person-to-Person Transmission of Alzheimer's Pathology
Prions are the misshapen proteins that replicate by inducing normal proteins to misfold and aggregate in the brain, leading to rare diseases such as mad cow and kuru. In recent years, scientists have discovered that similar processes of protein misfolding are at work in many neurodegenerative disorders, including Alzheimer's, Parkinson's and Lou Gehrig's disease.
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Possible Evidence for Person-to-Person Transmission of Alzheimer's Pathology
Sep 11,2015
Scientists Developed Novel Cell-Free Protein Synthesis Platform
    Cell-free protein synthesis (CFPS) represents an alternative to cell-based expression as it dramatically improves the development of engineered proteins.  Scientists from Northwestern University and Yale say they have developed a user-friendly technology to help scientists understand how proteins work and fix them when they are broken. They believe such knowledge could pave the way forRead more
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Scientists Developed Novel Cell-Free Protein Synthesis Platform
Sep 10,2015
Takeda to Collaborate with Gencia to Co-Develop MAGR Drugs
    Takeda Pharmaceutical will collaborate with Gencia to co-develop its new class of small molecule drugs as drug candidates for hematological and inflammatory diseases, in a collaboration that could generate more than $500 million for Gencia.  
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Takeda to Collaborate with Gencia to Co-Develop MAGR Drugs
Sep 10,2015
MRSA Vaccine Close to Reality
    NYU Langone Medical Center's scientist team says they have found out why a particular strain of Staphylococcus aureus, known as HA-MRSA, becomes more deadly than other variations. The new findings open up possible new pathways to vaccine development against this bacterium, which the Centers for Disease Control and Prevention says accounts for over 10,000 deathsRead more
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Sep 09,2015
Stem Cell Differentiation Being Regulated by New Method
    Scientists at the University of Helsinki in Finland say they have developed a new method that enables the activation of genes in a cell without changing the genome. Applications of the method include directing the differentiation of stem cells.     The method was developed by researchers Diego Balboa and Jere Weltner, who are working on theirRead more
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