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Top 10 Global Clinical Research Organizations in 2021| ADC, precision and deep cultivation for targeted drug delivery| What are the three major in vitro pharmacokinetic research methods?
Nov 18,2021
Consistency Evaluation of Oral Solid Preparation
As of May 2019, starting from the formal acceptance of the first conformity evaluation product in 2017, there have been nearly 900 oral solid preparations for conformity evaluation. The dosage forms include tablets, capsules, powders, sustained-release capsules, etc. At present, more than 200 product specifications have passed the consistency evaluation. The consistency evaluation ofRead more
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Consistency Evaluation of Oral Solid Preparation
Nov 18,2021
Storage Time of Oral Solid Preparations
FDA declaration 3.2.P.3.4 includes three contents. Acceptance criteria and test results of registered batches;Comparison table of equipment and control standards used in registered batches and commercial batches;Intermediate storage information. The contents of the first and second items may be familiar to everyone. Therefore, this article mainly introduces the third item, the key point of intermediateRead more
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Storage Time of Oral Solid Preparations
Nov 16,2021
Liver Microsome Model of Drug Metabolism Model in Vitro
For those drugs with low metabolic rate, high toxicity, or lack of sensitive detection methods, in vitro drug metabolism studies can eliminate the interference of internal factors and provide reliable theoretical data for the overall experiment. The liver microsomal model is one of the common in vitro models for studying drug metabolism in laboratories. ItRead more
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Liver Microsome Model of Drug Metabolism Model in Vitro
Nov 16,2021
Basic Parameters and Abbreviations in Pharmacokinetic Tests
Pharmacokinetic Parameters Pharmacokinetic parameters represent the parameters of the mathematical model of the process of drug absorption, distribution, excretion and structural transformation in the body. Absorption Dissolution: the degree to which the drug molecule is dissolved in the digestive tract Bioavailability: the degree of drug absorption Absolute bioavailability Maximum blood concentration (Cmax) Peak time (Tmax)Read more
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Basic Parameters and Abbreviations in Pharmacokinetic Tests
Nov 16,2021
Pre-clinical Research Escorts the Development of Innovative Drugs
The first challenge in drug development is the pre-clinical research of new drugs, which refers to the chemical synthesis or natural product purification research, drug analysis research, pharmacodynamics, pharmacokinetics, and toxicology that are carried out before the drug enters clinical research. And pharmaceutics research. Preclinical research on new drugs escorts the development of innovative drugs.Read more
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Pre-clinical Research Escorts the Development of Innovative Drugs
Nov 12,2021
Non-labeled Natural Product Target Identification and Validation
The structure of natural products is complex and rich, with a wide range of biological activities, and is an important source of new drug innovation. According to statistics, nearly half of the drugs approved by the U.S. Food and Drug Administration (FDA) for cancer treatment in the past 30 years Medicines are directly or indirectlyRead more
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Non-labeled Natural Product Target Identification and Validation
Nov 12,2021
Artificial Intelligence Helps Drug Development
On October 22, 2021, the research group of Academician Hualiang Jiang and Mingyue Zheng from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences published an article Drug target inference by mining transcriptional data using a novel graph convolutional network framework on Protein & Cell. Researchers applied the Twin Spectrogram Convolutional Network (SSGCN).
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Artificial Intelligence Helps Drug Development
Nov 12,2021
Target Validation and Drug Discovery
Since the completion of the Human Genome Project in 2003, researchers have been trying to find molecular targets related to specific phenotypes. Many experimental techniques have been developed for the confirmation of new disease targets and the discovery of lead compounds. In addition, the increase in the number of protein structures and the increase inRead more
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Target Validation and Drug Discovery
Nov 11,2021
Preparation Method and Related Synthesis Process of Chiral Drug
Overview At present, chiral drugs have occupied an important position in the global pharmaceutical market. Chiral drugs have high technical barriers, good economic benefits, high curative effect, low toxic and side effects, and low dosage. The research and development of chiral drugs has become an important development direction of the pharmaceutical industry. Preparation method ofRead more
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Preparation Method and Related Synthesis Process of Chiral Drug
Nov 11,2021
Chiral Drug Synthesis
Chiral drugs refer to drugs that contain chiral centers (including chiral carbon, chiral nitrogen, chiral sulfur, etc.) in their molecular structure. In January 1992, the FDA promulgated the "Development of Stereoisomer Drugs” technical research guidelines, giving guidance on the work that needs to be done in the research of stereoisomer drugs. In December 2006, theRead more
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Chiral Drug Synthesis