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Top 10 Global Clinical Research Organizations in 2021| ADC, precision and deep cultivation for targeted drug delivery| What are the three major in vitro pharmacokinetic research methods?
Nov 16,2021
Basic Parameters and Abbreviations in Pharmacokinetic Tests
Pharmacokinetic Parameters Pharmacokinetic parameters represent the parameters of the mathematical model of the process of drug absorption, distribution, excretion and structural transformation in the body. Absorption Dissolution: the degree to which the drug molecule is dissolved in the digestive tract Bioavailability: the degree of drug absorption Absolute bioavailability Maximum blood concentration (Cmax) Peak time (Tmax)Read more
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Basic Parameters and Abbreviations in Pharmacokinetic Tests
Nov 16,2021
Pre-clinical Research Escorts the Development of Innovative Drugs
The first challenge in drug development is the pre-clinical research of new drugs, which refers to the chemical synthesis or natural product purification research, drug analysis research, pharmacodynamics, pharmacokinetics, and toxicology that are carried out before the drug enters clinical research. And pharmaceutics research. Preclinical research on new drugs escorts the development of innovative drugs.Read more
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Pre-clinical Research Escorts the Development of Innovative Drugs
Nov 12,2021
Non-labeled Natural Product Target Identification and Validation
The structure of natural products is complex and rich, with a wide range of biological activities, and is an important source of new drug innovation. According to statistics, nearly half of the drugs approved by the U.S. Food and Drug Administration (FDA) for cancer treatment in the past 30 years Medicines are directly or indirectlyRead more
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Non-labeled Natural Product Target Identification and Validation
Nov 12,2021
Artificial Intelligence Helps Drug Development
On October 22, 2021, the research group of Academician Hualiang Jiang and Mingyue Zheng from the Shanghai Institute of Materia Medica, Chinese Academy of Sciences published an article Drug target inference by mining transcriptional data using a novel graph convolutional network framework on Protein & Cell. Researchers applied the Twin Spectrogram Convolutional Network (SSGCN).
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Artificial Intelligence Helps Drug Development
Nov 12,2021
Target Validation and Drug Discovery
Since the completion of the Human Genome Project in 2003, researchers have been trying to find molecular targets related to specific phenotypes. Many experimental techniques have been developed for the confirmation of new disease targets and the discovery of lead compounds. In addition, the increase in the number of protein structures and the increase inRead more
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Target Validation and Drug Discovery
Nov 11,2021
Preparation Method and Related Synthesis Process of Chiral Drug
Overview At present, chiral drugs have occupied an important position in the global pharmaceutical market. Chiral drugs have high technical barriers, good economic benefits, high curative effect, low toxic and side effects, and low dosage. The research and development of chiral drugs has become an important development direction of the pharmaceutical industry. Preparation method ofRead more
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Preparation Method and Related Synthesis Process of Chiral Drug
Nov 11,2021
Chiral Drug Synthesis
Chiral drugs refer to drugs that contain chiral centers (including chiral carbon, chiral nitrogen, chiral sulfur, etc.) in their molecular structure. In January 1992, the FDA promulgated the "Development of Stereoisomer Drugs” technical research guidelines, giving guidance on the work that needs to be done in the research of stereoisomer drugs. In December 2006, theRead more
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Chiral Drug Synthesis
Nov 08,2021
Two Leading CRO Organizaitons in America in 2020
Business Structure Comparison LabCorp and IQVIA are the world’s leading CRO organizaitons, and these two organizaitons have been catching up with you. LabCorp is mainly composed of two major businesses, LabCorp Diagnostics (LCD) and Covance Drug Development (CDD), and CDD is composed of Covance Inc., which was acquired in 2015, and is also the leaderRead more
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Nov 08,2021
Top 10 Global Clinical Research Organizations in 2021
In 2020, a global outbreak of the new crown epidemic disrupted the business activities of almost all companies, and the drug R&D and production of pharmaceutical companies was no exception. As a CRO/CDMO company serving pharmaceutical companies, its market share and global ranking have also changed when the global market order is chaotic.
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Top 10 Global Clinical Research Organizations in 2021
Nov 05,2021
Drug Local Toxicity Test
Local toxicity refers to the damaging effects of certain drugs directly caused by the contact parts of the body. It initially manifests as cell death at the site of direct contact. Mainly include irritation test, allergy test, hemolysis test. Irritation test: Irritation refers to the reversible inflammatory reaction to the administration site after the administrationRead more
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