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Top 10 Global Clinical Research Organizations in 2021| ADC, precision and deep cultivation for targeted drug delivery| What are the three major in vitro pharmacokinetic research methods?
Nov 04,2021
Influence of Hemolysis on Test Results
Specimen hemolysis is one of the most common interference and influence factors in clinical biochemical examination. Hemolysis leads to inaccurate test results, which cannot objectively reflect the patient's physical condition at that time. The influence of specimen hemolysis on clinical test results is as follows: 1. Influence on RBC Count and RBC Specific Volume  In hemolysisRead more
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Nov 03,2021
Abnormal Result Caused by Hemolysis of Blood Samples
⑴ Influence on biochemical results: Specimen hemolysis is the most common interference and influencing factor in clinical biochemical tests. Hemolysis has an impact on a considerable part of biochemical testing items. Among them, total bilirubin (TBIL), aspartate aminotransferase (AST), total protein (TP), and albumin (ALB) are significantly increased after hemolysis; significant after hemolysis The itemsRead more
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Nov 03,2021
Influence of Hemolysis on the Analysis of Biological Samples
Hemolysis refers to the rupture of red blood cells and the escape of hemoglobin into plasma or serum, which can occur in vivo and in vitro. The factors affecting hemolysis are also very complicated. After hemolysis of plasma and serum, many physiological components such as hemoglobin, bilirubin, phospholipids, etc. increase significantly. These components may affectRead more
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Nov 03,2021
Hemolysis Test
Hemolysis test: refers to the hemolysis and red blood cell aggregation caused by pharmaceutical preparations. Hemolytic reactions include immune hemolysis and non-immune hemolysis. 1. Prepare 2% Red Blood Cells Baoding rabbits, draw blood from the heart 5 m, add 0.2 ml of anticoagulant EDTA, wash with PBS, centrifuge to remove the white blood cells onRead more
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Nov 03,2021
Common Biological Experiment Testing Items
Biological Test Items Under GLP Regulations: Single and multiple dose toxicity test (rodent)Single and multiple dose toxicity test (non-rodent) Reproductive toxicity test (I, II)Genetic toxicity test (Ames, micronucleus, chromosome aberration) Local toxicity test (allergic, irritation, hemolysis) Immunogenicity/Immune toxicology test Safety pharmacology test Toxicokinetic test Carry out systematic pharmacokinetic studies according to the requirements of theRead more
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Oct 29,2021
Factors Affecting Metabolism
Metabolism is the process of changing the chemical structure of drugs in the human body. The main organ that can metabolize drugs in the human body is the liver, followed by the small intestine, kidney, lung, and brain tissue. For more details, please read Factors Affecting Pharmacokinetics of Drugs. Factors Affecting Drug Metabolism: Genetic factors:Read more
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Factors Affecting Metabolism
Oct 28,2021
Factors Affecting Drug Metabolism
Drug metabolism refers to the chemical change process of drugs in the body. Most drugs lose their activity after being metabolized, and are converted into extremely high water-soluble metabolites, which are beneficial to excretion from the body. There are also some drugs that are hardly metabolized in the body and are excreted as original drugs.Read more
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Oct 28,2021
Application of Yeast Expression System
Background Yeast expression system is the most economical and efficient eukaryotic protein expression system, which can successfully achieve intracellular expression or secretory expression, and its amplification medium is relatively cheap, and the culture conditions are not demanding, so it is suitable for industrial amplification. Like mammalian cell expression systems, yeast protein expression systems can performRead more
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Application of Yeast Expression System
Oct 28,2021
Yeast Expression System and Method
The Production of Yeast Expression System The development of genetic engineering technology has shown broad prospects for the synthesis and production of foreign proteins by microorganisms. For a long time, people have used E. coli as a host to express a variety of proteins. This is because E. coli has several advantages, such as clearRead more
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Yeast Expression System and Method
Oct 27,2021
Immunofluorescence Technique
Immunofluorescence technique (immunofluorescence technique) is also known as fluorescent antibody technique. Founded in the early 1940s, in 1942, Coons et al. reported several times that antibodies were labeled with fluorescein isocyanate. It is a technology established on the basis of immunology, biochemistry and microscopy. Immunofluorescence technology includes fluorescent antibody technology and fluorescent antigen technology, becauseRead more
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Immunofluorescence Technique